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BioMed Research International
Volume 2015, Article ID 351831, 7 pages
http://dx.doi.org/10.1155/2015/351831
Research Article

High Body Mass Index Is an Indicator of Maternal Hypothyroidism, Hypothyroxinemia, and Thyroid-Peroxidase Antibody Positivity during Early Pregnancy

1Department of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Affiliated Hospital of China Medical University, No. 155 Nanjing North Street, Shenyang, Liaoning 110001, China
2Shenyang Women’s and Children’s Hospital, No. 87 Danan Street, Shenyang, Liaoning 110001, China
3Department of Obstetrics and Gynecology, No. 202 Hospital of People’s Liberation Army, No. 5 Guangrong Street, Shenyang, Liaoning 110001, China
4Dalian Obstetrics and Gynecology Hospital, No. 1 Dunhuang Street, Dalian, Liaoning 116001, China
5Department of Obstetrics and Gynecology, The First Hospital of China Medical University, No. 155 Nanjing North Street, Shenyang, Liaoning 110001, China
6Department of Endocrinology, The First Affiliated Hospital of Dalian Medical University, No. 222 Zhongshan Road, Dalian, Liaoning 116001, China
7Department of Endocrinology, No. 202 Hospital of People’s Liberation Army, No. 5 Guangrong Street, Shenyang 110001, China
8Department of Endocrinology, Dalian Municipal Central Hospital, Dalian Medical University, No. 826 Xinan Road, Dalian, Liaoning 116001, China
9Department of Endocrinology, The First Hospital of Dandong, No. 76 Baoshan Street, Dandong, Liaoning 118001, China
10Shenyang Women and Children Health Care Center, No. 74 Chongshan East Street, Shenyang, Liaoning 110001, China

Received 12 March 2015; Revised 2 June 2015; Accepted 9 July 2015

Academic Editor: Abel Romero-Corral

Copyright © 2015 Cheng Han et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. Maternal thyroid dysfunction in early pregnancy may increase the risk of adverse pregnancy complications and neurocognitive deficiencies in the developing fetus. Currently, some researchers demonstrated that body mass index (BMI) is associated with thyroid function in nonpregnant population. Hence, the American Thyroid Association recommended screening thyroid function in obese pregnant women; however, the evidence for this is weak. For this purpose, our study investigated the relationship between high BMI and thyroid functions during early pregnancy in Liaoning province, an iodine-sufficient region of China. Methods. Serum thyroid stimulating hormone (TSH), free thyroxine (FT4), thyroid-peroxidase antibody (TPOAb), thyroglobulin antibody (TgAb) concentration, urinary iodine concentration (UIC), and BMI were determined in 6303 pregnant women. Results. BMI ≥ 25 kg/m2 may act as an indicator of hypothyroxinemia and TPOAb positivity and BMI ≥ 30 kg/m2 was associated with increases in the odds of hypothyroidism, hypothyroxinemia, and TPOAb positivity. The prevalence of isolated hypothyroxinemia increased among pregnant women with BMI > 24 kg/m2. Conclusions. High BMI during early pregnancy may be an indicator of maternal thyroid dysfunction; for Asian women whose BMI > 24 kg/m2 and who are within 8 weeks of pregnancy, thyroid functions should be assessed especially.