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BioMed Research International
Volume 2015, Article ID 351862, 9 pages
http://dx.doi.org/10.1155/2015/351862
Research Article

Comparison of Lyophilized Glutaraldehyde-Preserved Bovine Pericardium with Different Vascular Prostheses for Use as Vocal Cords Implants: Experimental Study

1Department of Surgical Research, Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas, Tlalpan, 14080 Mexico City, DF, Mexico
2Department of Morphology, Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas, Tlalpan, 14080 Mexico City, DF, Mexico
3Department of Otolaryngology-Head and Neck Surgery, Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas, Tlalpan, 14080 Mexico City, DF, Mexico
4Medical Direction, Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas, Tlalpan, 14080 Mexico City, DF, Mexico

Received 20 January 2015; Revised 27 March 2015; Accepted 13 April 2015

Academic Editor: Esmaiel Jabbari

Copyright © 2015 J. Raúl Olmos-Zuñiga et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

This study compared the use of lyophilized glutaraldehyde-preserved bovine pericardium (LGPBP), polytetrafluoroethylene (PTFE), polyethylene terephthalate (PET), and Teflon felt (TF) as implants for vocal cords (VC) medialization and aimed to assess the endoscopic, macroscopic, and microscopic VC changes after medialization in a canine model. In 18 mongrel dogs, the right VC were medialized with LGPBP and the left were implanted as follows: Group I (): LGPBP and PTFE; Group II (): LGPBP and PET; Group III (): LGPBP and TF. Surgical handling of the implants was compared. Three months after surgery, macroscopic and microscopic changes of VC and implants were evaluated. LGPBP offered the best surgical handling (, Kruskal-Wallis). TF implants showed extrusion (, Kruskal-Wallis) and severe inflammation. All VC formed fibrous capsules around the implants; the ones developed by LGPBP implants were thinner (, ANOVA, Tukey). VC implanted with synthetic materials showed eosinophilic infiltration (, Kruskal-Wallis). We concluded that the LGPBP could be used as an implant for VC medialization because it is biocompatible, easy to handle and remove during surgical procedures, and nonabsorbable or extrudable and produces an inflammatory reaction similar to PTFE and PET.