Heart Failure: Advanced Development in Genetics and Epigenetics

Table 2

Main dilated cardiomyopathy-causing genes hypertrophic cardiomyopathy.

Gene	Protein	OMIM	% of familial HCM cases
MYH7	Myosin heavy chain	160760	40%
	Cardiac muscle beta isoform	192600
MYBPC3	Myosin-binding protein C, cardiac-type	600958	40%
TNNT2	Troponin T, cardiac muscle	115195	5%
TNNI3	Troponin I, cardiac muscle	191044	5%
TPM1	Tropomyosin 1 alpha chain	115196	2%
		191010
MYL2	Myosin regulatory light chain 2	160781	Unknown
	ventricular/cardiac muscle isoform	608758
MYL3	Myosin light polypeptide 3	160790	1%
		608751