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BioMed Research International
Volume 2015 (2015), Article ID 359392, 14 pages
http://dx.doi.org/10.1155/2015/359392
Research Article

Prognostic Value of Homotypic Cell Internalization by Nonprofessional Phagocytic Cancer Cells

1Department of Radiation Oncology, University Hospital Erlangen, 91054 Erlangen, Germany
2Department of Pathology, University Hospital Erlangen, 91054 Erlangen, Germany

Received 13 February 2015; Accepted 17 June 2015

Academic Editor: Franco M. Buonaguro

Copyright © 2015 Manuela Schwegler et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. National Library of Medicine (US), “Medical Subject Headings,” National Library of Medicine (US), Bethesda, Md, USA, 2011, http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?mode=&index=25547&field=all&HM=&II=&PA=&form=&input.
  2. S. Fais, “Cannibalism: a way to feed on metastatic tumors,” Cancer Letters, vol. 258, no. 2, pp. 155–164, 2007. View at Publisher · View at Google Scholar
  3. K. Gupta and P. Dey, “Cell cannibalism: diagnostic marker of malignancy,” Diagnostic Cytopathology, vol. 28, no. 2, pp. 86–87, 2003. View at Publisher · View at Google Scholar · View at Scopus
  4. L. Lugini, P. Matarrese, A. Tinari et al., “Cannibalism of live lymphocytes by human metastatic but not primary melanoma cells,” Cancer Research, vol. 66, no. 7, pp. 3629–3638, 2006. View at Publisher · View at Google Scholar · View at Scopus
  5. P. V. Kumar, M. Hosseinzadeh, and G. R. Bedayat, “Cytologic findings of medulloblastoma in crush smears,” Acta Cytologica, vol. 45, no. 4, pp. 542–546, 2001. View at Publisher · View at Google Scholar · View at Scopus
  6. W. T. Abodief, P. Dey, and O. Al-Hattab, “Cell cannibalism in ductal carcinoma of breast,” Cytopathology, vol. 17, no. 5, pp. 304–305, 2006. View at Publisher · View at Google Scholar · View at Scopus
  7. C. E. Cano, M. J. Sandí, T. Hamidi et al., “Homotypic cell cannibalism, a cell-death process regulated by the nuclear protein 1, opposes to metastasis in pancreatic cancer,” EMBO Molecular Medicine, vol. 4, no. 9, pp. 964–979, 2012. View at Publisher · View at Google Scholar · View at Scopus
  8. M. Schwegler, A. M. Wirsing, A. J. Dollinger et al., “Clearance of primary necrotic cells by non-professional phagocytes,” Biology of the Cell, 2015. View at Publisher · View at Google Scholar
  9. F. Lozupone, M. Perdicchio, D. Brambilla et al., “The human homologue of Dictyostelium discoideum phg1A is expressed by human metastatic melanoma cells,” EMBO Reports, vol. 10, no. 12, pp. 1348–1354, 2009. View at Publisher · View at Google Scholar · View at Scopus
  10. L. V. Distel, R. Fickenscher, K. Dietel et al., “Tumour infiltrating lymphocytes in squamous cell carcinoma of the oro- and hypopharynx: prognostic impact may depend on type of treatment and stage of disease,” Oral Oncology, vol. 45, no. 10, pp. e167–e174, 2009. View at Publisher · View at Google Scholar · View at Scopus
  11. D. Pretscher, L. V. Distel, G. G. Grabenbauer, M. Wittlinger, M. Buettner, and G. Niedobitek, “Distribution of immune cells in head and neck cancer: CD8+ T-cells and CD20+ B-cells in metastatic lymph nodes are associated with favourable outcome in patients with oro- and hypopharyngeal carcinoma,” BMC Cancer, vol. 9, article 292, 2009. View at Publisher · View at Google Scholar · View at Scopus
  12. M. Tabachnyk, L. V. R. Distel, M. Büttner et al., “Radiochemotherapy induces a favourable tumour infiltrating inflammatory cell profile in head and neck cancer,” Oral Oncology, vol. 48, no. 7, pp. 594–601, 2012. View at Publisher · View at Google Scholar · View at Scopus
  13. G. G. Grabenbauer, G. Lahmer, L. Distel, and G. Niedobitek, “Tumor-infiltrating cytotoxic T cells but not regulatory T cells predict outcome in anal squamous cell carcinoma,” Clinical Cancer Research, vol. 12, no. 11, pp. 3355–3360, 2006. View at Publisher · View at Google Scholar · View at Scopus
  14. N. Tehrany, J. Kitz, M. Rave-Frank et al., “High-grade acute organ toxicity and p16 expression as positive prognostic factors in primary radio(chemo)therapy for patients with head and neck squamous cell carcinoma,” Strahlentherapie und Onkologie, vol. 191, no. 7, pp. 566–572, 2015. View at Publisher · View at Google Scholar
  15. Y. Wang and X. N. Wang, “Cell-in-cell: a virgin land of cell biology,” OncoImmunology, vol. 2, no. 10, Article ID e25988, 2014. View at Publisher · View at Google Scholar
  16. S. Kojima, H. Sekine, I. Fukui, and H. Ohshima, “Clinical significance of ‘cannibalism’ in urinary cytology of bladder cancer,” Acta Cytologica, vol. 42, no. 6, pp. 1365–1369, 1998. View at Publisher · View at Google Scholar · View at Scopus
  17. R. A. Caruso, A. O. Muda, A. Bersiga, L. Rigoli, and C. Inferrera, “Morphological evidence of neutrophil-tumor cell phagocytosis (cannibalism) in human gastric adenocarcinomas,” Ultrastructural Pathology, vol. 26, no. 5, pp. 315–321, 2002. View at Publisher · View at Google Scholar · View at Scopus
  18. L. Lugini, F. Lozupone, P. Matarrese et al., “Potent phagocytic activity discriminates metastatic and primary human malignant melanomas: a key role of ezrin,” Laboratory Investigation, vol. 83, no. 11, pp. 1555–1567, 2003. View at Publisher · View at Google Scholar · View at Scopus
  19. L. Galluzzi, I. Vitale, J. M. Abrams et al., “Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012,” Cell Death & Differentiation, vol. 19, no. 1, pp. 107–120, 2012. View at Publisher · View at Google Scholar