How to Use SNP_TATA_Comparator to Find a Significant Change in Gene Expression Caused by the Regulatory SNP of This Gene’s Promoter via a Change in Affinity of the TATA-Binding Protein for This Promoter

Figure 1

How to use the Web service SNP_TATA_Comparator [62] to find a significant change in gene expression caused by SNPs of this gene’s promoter via a change in affinity of the TATA-binding protein (TBP) for this promoter in the cases of (a) a known biomedical SNP marker and (b) a nearby candidate SNP marker. Solid, dotted, and dashed arrows are the gene, transcript, and sequence lists, respectively, from Ensembl [5] and GENCODE [6] databases of the reference human genome, hg19. Dash-and-dot arrows are an estimate of the statistical significance (-score, value) of deviation of the gene expression in patients carrying minor alleles, relative to the ancestral allele, (1)–(4) and Algorithm 1.

(a)

(b)