BioMed Research International / 2015 / Article / Fig 1

Review Article

Primary Retinal Cultures as a Tool for Modeling Diabetic Retinopathy: An Overview

Figure 1

The diagram summarizes the various interacting pathways leading to oxidative stress upon exposure to high glucose concentrations. Most of the pathways are considered to play a role in retinal neuron apoptosis and Müller glia activation. It is still controversial if Müller glia activation is also responsible for neuronal cell death.