Ordinary and Activated Bone Grafts: Applied Classification and the Main Features

Table 2

Compositions of gene constructions developed for induction of reparative osteogenesis (as components of gene-activated bone grafts or gene-cellular products).

Number	Transgene	Vector	References
Genes encoding growth factors/hormones
1	Angiopoietin-1		[157]
2	BMP-2	Plasmid DNA	[156]
		Adenoviral	[155]
		Lentiviral	[158]
		Liposomal	[159]
3	BMP-4	Plasmid DNA	[160]
		Retroviral	[154]
4	BMP-6	Plasmid DNA	[161]
		Adenoviral	[162]
		Adenoassociated	[163]
		Lentiviral	[161]
5	BMP-7 (OP-1)	Plasmid DNA	[164]
		Adenoviral	[165]
		Adenoassociated	[166]
		Retroviral	[167]
6	BMP-9	Plasmid DNA	[168]
		Adenoviral	[169]
7	BMP-12	Plasmid DNA	[170]
8	Cyclooxygenase-2 (Cox-2)	Retroviral	[171]
9	Erythropoietin (EPO)	Adenoviral	[172]
10	Epidermal Growth Factor (EGF)	Plasmid DNA	[173]
11	bFGF	Plasmid DNA	[174]
12	HGF	Adenoviral	[175]
13	HIF-1α	Lentiviral	[176]
14	IGF-1	Plasmid DNA	[177]
15	Integrin-α5	Lentiviral	[178]
16	LIM mineralization protein-1 (LMP-1)	Retroviral	[179]
17	LMP-3	Adenoviral	[180]
18	Nell-1	Adenoviral	[181]
19	Osterix	Retroviral	[182]
20	PDGF-А	Adenoviral	[183]
21	PDGF-B	Plasmid DNA	[184]
		Adenoviral	[183]
22	Parathyroid hormone (amino acids 1–34)	Plasmid DNA	[185]
23	TGF-β1	Nonviral vector (K)16GRGDSPC	[186]
24	VEGF-А	Plasmid DNA	[187]
		Adenoviral	[188]
25	BMP-2 + BMP-7	Adenoviral	[189]
26	BMP-2 + BMP-6	Adenoviral	[190]
27	BMP-2 + IHH	Adenoviral	[191]
28	BMP-2 + VEGF	Adenoviral	[192]
29	BMP-2 + VEGF + IGF-1 + TGF-β1		[193]
30	BMP-7 + PDGF-b	Adenoviral	[194]
31	RANKL + VEGF	Adenoassociated	[195]
32	BMP-2/BMP-7	Plasmid DNA	[196]
33	BMP-2/BMP-4	Liposomal	[197]
34	BMP-6/BMP-9	Adenoviral	[198]
35	BMP-6/VEGF	Adenoviral	[199]
36	BMP-7/IGF-1	Adenoviral	[200]
37	BMP-7/OPG	Plasmid DNA	[201]
Genes encoding transcriptional factors
38	Cbfa1	Lentiviral	[202]
		Adenoviral	[203]
39	c-myb	Plasmid DNA	[204]
40	Runx2	Adenoviral	[205]
		Retroviral	[206]
41	SOX9	Adenoassociated	[207]
42	caALK6 + Runx2	Plasmid DNA	[208]