BioMed Research International / 2015 / Article / Tab 1

Research Article

Pharmacokinetics Interaction between Imatinib and Genistein in Rats

Table 1

The main pharmacokinetic parameters of imatinib in five groups ().

ParametersABCDE

(mg⋅L−1)14.511 ± 2.82111.036 ± 1.681*10.810 ± 1.685*12.936 ± 1.34813.136 ± 3.116
(h)2.899 ± 0.8642.298 ± 0.6082.200 ± 0.6042.173 ± 1.0103.315 ± 0.288
(h)2.600 ± 0.5482.400 ± 0.5482.800 ± 0.4473.0003.400 ± 0.548
Vz/ (L⋅kg−1)1227.409 ± 323.9531347.24 ± 263.741288.052 ± 369.454978.843 ± 513.0821418.396 ± 348.368
CLz/ (L⋅kg−1)300.125 ± 49.474413.894 ± 41.234406.776 ± 30.891311.401 ± 43.075295.466 ± 59.811
AUC(0–) (g⋅h⋅L−1)108.145 ± 18.06277.741 ± 7.592*78.914 ± 6.625*104.072 ± 15.944110.164 ± 18.592
AUC(0–) (mg⋅h⋅L−1)109.010 ± 18.34377.932 ± 7.766*79.070 ± 6.635*104.491 ± 15.6951111.310 ± 18.701
MRT(0–) (h)6.182 ± 0.5095.561 ± 0.7365.877 ± 0.1406.206 ± 0.7246.538 ± 0.334
MRT(0–) (h)6.356 ± 0.6935.611 ± 0.7705.922 ± 0.1006.301 ± 0.8746.781 ± 0.409

= significance in comparison to group A (ANOVA).