Pharmacokinetics Interaction between Imatinib and Genistein in Rats

Table 1

The main pharmacokinetic parameters of imatinib in five groups ().

Parameters	A	B	C	D	E
(mg⋅L^−1)	14.511 ± 2.821	11.036 ± 1.681^*	10.810 ± 1.685^*	12.936 ± 1.348	13.136 ± 3.116
(h)	2.899 ± 0.864	2.298 ± 0.608	2.200 ± 0.604	2.173 ± 1.010	3.315 ± 0.288
(h)	2.600 ± 0.548	2.400 ± 0.548	2.800 ± 0.447	3.000	3.400 ± 0.548
Vz/ (L⋅kg^−1)	1227.409 ± 323.953	1347.24 ± 263.74	1288.052 ± 369.454	978.843 ± 513.082	1418.396 ± 348.368
CLz/ (L⋅kg^−1)	300.125 ± 49.474	413.894 ± 41.234	406.776 ± 30.891	311.401 ± 43.075	295.466 ± 59.811
AUC(0–) (g⋅h⋅L^−1)	108.145 ± 18.062	77.741 ± 7.592^*	78.914 ± 6.625^*	104.072 ± 15.944	110.164 ± 18.592
AUC(0–∞) (mg⋅h⋅L^−1)	109.010 ± 18.343	77.932 ± 7.766^*	79.070 ± 6.635^*	104.491 ± 15.695	1111.310 ± 18.701
MRT(0–) (h)	6.182 ± 0.509	5.561 ± 0.736	5.877 ± 0.140	6.206 ± 0.724	6.538 ± 0.334
MRT(0–∞) (h)	6.356 ± 0.693	5.611 ± 0.770	5.922 ± 0.100	6.301 ± 0.874	6.781 ± 0.409

= significance in comparison to group A (ANOVA).