Research Article
Pharmacokinetics Interaction between Imatinib and Genistein in Rats
Table 2
The main pharmacokinetic parameters of N-desmethyl imatinib in five groups (
).
| | Parameters | A | B | C | D | E |
| | (mg⋅L−1) | 0.566 ± 0.063 | 0.694 ± 0.111 | 0.658 ± 0.044 | 0.546 ± 0.145 | 0.552 ± 0.110 | | (h) | 4.099 ± 1.415 | 3.864 ± 1.563 | 3.857 ± 0.949 | 4.559 ± 0.605 | 4.736 ± 1.323 | | (h) | 3.800 ± 1.304 | 4.400 ± 1.517 | 4.000 ± 1.871 | 4.600 ± 1.949 | 4.600 ± 1.342 | | Vz/ (L⋅kg−1) | 37429.442 ± 12484.149 | 29407.106 ± 12819.755 | 30990.850 ± 5752.33 | 42622.588 ± 14954.107 | 44070.769 ± 13901.919 | | CLz/ (L⋅kg−1) | 6435.171 ± 797.154 | 5250.116 ± 512.648 | 5709.087 ± 941.271 | 6374.325 ± 1785.552 | 6459.427 ± 760.373 | | AUC(0–) (mg⋅h⋅L−1) | 4.890 ± 0.573 | 5.978 ± 0.680 | 5.608 ± 0.951 | 5.178 ± 1.165 | 4.798 ± 0.575 | | AUC(0–∞) (mg⋅h⋅L−1) | 5.037 ± 0.650 | 6.144 ± 0.629 | 5.748 ± 1.087 | 5.380 ± 1.617 | 5.007 ± 0.571 | | MRT(0–) (h) | 7.088 ± 0.548 | 6.751 ± 0.659 | 6.762 ± 0.518 | 7.205 ± 0.757 | 7.276 ± 0.668 | | MRT(0–∞) (h) | 7.752 ± 1.062 | 7.415 ± 1.180 | 7.271 ± 0.925 | 8.152 ± 0.800 | 8.300 ± 1.219 |
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