BioMed Research International / 2015 / Article / Tab 2

Research Article

Pharmacokinetics Interaction between Imatinib and Genistein in Rats

Table 2

The main pharmacokinetic parameters of N-desmethyl imatinib in five groups ().

ParametersABCDE

(mg⋅L−1)0.566 ± 0.0630.694 ± 0.1110.658 ± 0.0440.546 ± 0.1450.552 ± 0.110
(h)4.099 ± 1.4153.864 ± 1.5633.857 ± 0.9494.559 ± 0.6054.736 ± 1.323
(h)3.800 ± 1.3044.400 ± 1.5174.000 ± 1.8714.600 ± 1.9494.600 ± 1.342
Vz/ (L⋅kg−1)37429.442 ± 12484.14929407.106 ± 12819.75530990.850 ± 5752.3342622.588 ± 14954.10744070.769 ± 13901.919
CLz/ (L⋅kg−1)6435.171 ± 797.1545250.116 ± 512.6485709.087 ± 941.2716374.325 ± 1785.5526459.427 ± 760.373
AUC(0–) (mg⋅h⋅L−1)4.890 ± 0.5735.978 ± 0.6805.608 ± 0.9515.178 ± 1.1654.798 ± 0.575
AUC(0–) (mg⋅h⋅L−1)5.037 ± 0.6506.144 ± 0.6295.748 ± 1.0875.380 ± 1.6175.007 ± 0.571
MRT(0–) (h)7.088 ± 0.5486.751 ± 0.6596.762 ± 0.5187.205 ± 0.7577.276 ± 0.668
MRT(0–) (h)7.752 ± 1.0627.415 ± 1.1807.271 ± 0.9258.152 ± 0.8008.300 ± 1.219