Big Data Analytics in Healthcare

Table 2

Summary of popular methods and toolkits with their applications.

Toolkit name	Category	Selected applications
Onto-Express [139, 140]	Pathway analysis	Breast cancer [141]
GoMiner [142]	Pathway analysis	Pancreatic cancer [143]
ClueGo [144]	Pathway analysis	Colorectal tumors [145]
GSEA [146]	Pathway analysis	Diabetes [147]
Pathway-Express [148]	Pathway analysis	Leukemia [149]
Recon 2 [150]	Reconstruction of metabolic networks	Drug target prediction studies [151]
Boolean methods [135, 152, 153]	Reconstruction of gene regulatory networks	Cardiac differentiation [154]
ODE models [155–158]	Reconstruction of gene regulatory networks	Cardiac development [158]