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BioMed Research International
Volume 2015 (2015), Article ID 373252, 5 pages
http://dx.doi.org/10.1155/2015/373252
Research Article

A Functional Variant at miR-520a Binding Site in PIK3CA Alters Susceptibility to Colorectal Cancer in a Chinese Han Population

1Department of Oncology, Danyang People’s Hospital, Danyang 213000, China
2Department of Oncology, Affiliated Zhongda Hospital of Southeast University, Nanjing 210009, China
3Department of Central Laboratory, Affiliated People’s Hospital of Jiangsu University, Zhenjiang 212002, China
4Department of Oncology, Affiliated People’s Hospital of Jiangsu University, Zhenjiang 212002, China
5Department of Clinical Laboratory, Taixing People’s Hospital, Taixing 225400, China

Received 25 June 2014; Accepted 12 January 2015

Academic Editor: Pedro Moral

Copyright © 2015 Lifang Ding et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

An increasing body of evidence has indicated that polymorphisms in the miRNA binding site of target gene can alter the ability of miRNAs to bind their target genes and modulate the risk of cancer. We aimed to investigate the association between a miR-520a binding site polymorphism rs141178472 in the PIK3CA 3′-UTR and the risk of colorectal cancer (CRC) in a Chinese Han population. The polymorphism rs141178472 was analyzed in a case-control study, including 386 CRC patients and 394 age- and sex-matched controls; the relationship between the polymorphism and the risk of colorectal cancer was examined. Individuals carrying the rs141178472 CC genotype or C allele had an increased risk of developing CRC (CC versus TT, OR (95% CI): 1.716 (1.084–2.716), ; C versus T, OR (95% CI): 1.258 (1.021–1.551), . Furthermore, the expression of PIK3CA was detected in the peripheral blood mononucleated cell of CRC patients, suggesting that mRNA levels of PIK3CA might be associated with SNP rs141178472. These findings provide evidence that a miR-520a binding site polymorphism rs141178472 in the PIK3CA 3′-UTR may play a role in the etiology of CRC.