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BioMed Research International
Volume 2015, Article ID 373716, 11 pages
Research Article

Parameterization of the Age-Dependent Whole Brain Apparent Diffusion Coefficient Histogram

Department of Diagnostic and Interventional Neuroradiology, University Hospital Tübingen, Tübingen, Germany

Received 7 July 2015; Revised 4 September 2015; Accepted 10 September 2015

Academic Editor: Jinyuan Zhou

Copyright © 2015 Uwe Klose et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Purpose. The distribution of apparent diffusion coefficient (ADC) values in the brain can be used to characterize age effects and pathological changes of the brain tissue. The aim of this study was the parameterization of the whole brain ADC histogram by an advanced model with influence of age considered. Methods. Whole brain ADC histograms were calculated for all data and for seven age groups between 10 and 80 years. Modeling of the histograms was performed for two parts of the histogram separately: the brain tissue part was modeled by two Gaussian curves, while the remaining part was fitted by the sum of a Gaussian curve, a biexponential decay, and a straight line. Results. A consistent fitting of the histograms of all age groups was possible with the proposed model. Conclusions. This study confirms the strong dependence of the whole brain ADC histograms on the age of the examined subjects. The proposed model can be used to characterize changes of the whole brain ADC histogram in certain diseases under consideration of age effects.