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BioMed Research International
Volume 2015, Article ID 374616, 5 pages
Research Article

Atrial Fibrillation and Coronary Artery Disease as Risk Factors of Retinal Artery Occlusion: A Nationwide Population-Based Study

1Graduate Institute of Biomedical Informatics, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan
2Department of Ophthalmology, Taipei City Hospital, Zhongxiao Branch, Taipei 115, Taiwan
3Department of Neurology, Cathay General Hospital, Sijhih Branch, Taipei, Taiwan
4School of Medicine, National Yang-Ming University, Taipei 115, Taiwan
5Ministry of Health and Welfare, No. 488, Sec. 6, Zhongxiao E. Road, Taipei 115, Taiwan

Received 30 March 2015; Accepted 26 April 2015

Academic Editor: Jose Javier Garcia-Medina

Copyright © 2015 Ju-Chuan Yen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


We use Taiwanese national health insurance research database (NHIRD) to investigate whether thrombolism (carotid artery disease (CAD) as a surrogate) or embolism (atrial fibrillation (AF) as a surrogate) plays roles in later retinal artery occlusion (RAO) development and examine their relative weights. The relative risks of RAO between AF and CAD patients and controls were compared by estimating the crude hazard ratio with logistic regression. Kaplan-Meier analysis was used to calculate the cumulative incidence rates of developing RAO, and a log-rank test was used to analyze the differences between the survival curves. Separate Cox proportional hazard regressions were done to compute the RAO-free rate after adjusting for possible confounding factors such as age and sex. The crude hazard ratios were 7.98 for the AF group and 5.27 for the CAD group, and the adjusted hazard ratios were 8.32 and 5.34 for the AF and CAD groups, respectively. The observation time with RAO-free was shorter for AF compared with CAD group (1490 versus 1819 days). AF and CAD were both risk factors for RAO with different hazard ratios. To tackle both AF and CAD is crucial for curbing RAO.