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BioMed Research International
Volume 2015 (2015), Article ID 379071, 7 pages
Research Article

Biomarkers of Brain Damage: S100B and NSE Concentrations in Cerebrospinal Fluid—A Normative Study

1Laboratory for CSF and Neuroimmunology, Topelex Ltd., 190 00 Prague, Czech Republic
2Department of Neurology, The Military University Hospital Prague, 169 02 Prague, Czech Republic
3Department of Biology and Medical Genetics, Charles University 2nd Faculty of Medicine and University Hospital Motol, 150 06 Prague, Czech Republic
4Department of Biochemistry and Microbiology, The Institute of Chemical Technology, 166 28 Prague, Czech Republic

Received 27 June 2014; Revised 31 August 2014; Accepted 20 October 2014

Academic Editor: Diego Gazzolo

Copyright © 2015 Lenka Hajduková et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


NSE and S100B belong among the so-called structural proteins of the central nervous system (CNS). Lately, this group of structural proteins has been profusely used as specific biomarkers of CNS tissue damage. So far, the majority of the research papers have focused predominantly on the concentrations of these proteins in blood in relation to CNS damage of various origins. Considering the close anatomic and functional relationship between the brain or spinal cord and cerebrospinal fluid (CSF), in case of a CNS injury, a rapid and pronounced increase of the concentrations of structural proteins specifically in CSF takes place. This study inquires into the physiological concentrations of NSE and S100B proteins in CSF, carried out on a sufficiently large group of 601 patients. The detected values can be used for determination of a normal reference range in CSF in a clinical laboratory diagnostics.