Implication of Caspase-3 as a Common Therapeutic Target for Multineurodegenerative Disorders and Its Inhibition Using Nonpeptidyl Natural Compounds
Hydrogen bonding interaction of peptidyl and nonpeptidyl inhibitors with caspase-3. (a) Hydrogen bonding interaction of peptidyl inhibitor with caspase-3. (b) Common hydrogen bonding interaction of rosmarinic acid with caspase-3. (Ligand/inhibitor: red; amino acids of caspase-3 interacting with inhibitors via hydrogen bonding: blue; Unk0: rosmarinic acid.)
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