Research Article

Study of Cytotoxic Effects of Benzonitrile Pesticides

Table 1

The inhibition coefficients (%) for 24 h exposure and (%) for 48 h exposure of benzonitrile pesticides and their microbial metabolic products on Hep G2 cells for concentrations 25 mg/L, 50 mg/L, and 100 mg/L.

Compounds (%)
25 mg/L
(%)
25 mg/L
(%)
50 mg/L
(%)
50 mg/L
(%)
100 mg/L
(%)
100 mg/L

BRX20 ± 145 ± 352 ± 177 ± 292 ± 495 ± 3
BRAC8 ± 0,411 ± 110 ± 110 ± 115 ± 120 ± 2
BRAMNDNDND9 ± 0,5ND12 ± 2
CHX50 ± 372 ± 270 ± 490 ± 290 ± 299 ± 1
CHXAC10 ± 117 ± 225 ± 335 ± 250 ± 256 ± 3
CHXAMND 9 ± 1ND4 ± 0,110 ± 113 ± 1
DCBNDNDND14 ± 1ND15 ± 2
DCBANDNDNDND20 ± 212 ± 1
BAMND3 ± 0,2ND4 ± 0,210 ± 113 ± 3
IOX50 ± 358 ± 370 ± 488 ± 5100 ± 5100 ± 4
IOXACND3 ± 0,2ND10 ± 2ND19 ± 2
IOXAMND NDNDNDND16 ± 1

BRX: 3,5-dibromo-4-hydroxybenzonitrile, BRAC: 3,5-dibromo-4-hydroxybenzoic acid, BRAM: 3,5-dibromo-4-hydroxybenzamide, DCB: 2,6-dichlorobenzonitrile, DCBA: 2,6-dichlorobenzoic acid, BAM: 2,6-dichlorobenzamide, CHX: 3,5-dichloro-4-hydroxybenzonitrile, CHXAC: 3,5-dichloro-4-hydroxybenzoic acid, CHXAM: 3,5-dichloro-4-hydroxybenzamide, IOX: 3,5-diiodo-4-hydroxybenzonitrile, IOXAC: 3,5-diiodo-4-hydroxybenzoic acid, and IOXAM: 3,5-diiodo-4-hydroxybenzamide; ND: below detection limit; : the solubility of DCB in water is around 20 mg/L; therefore the inhibitions at concentrations 50 and 100 mg/L are only indicative; ±: standard deviation of 3 parallels.