TOP2A Amplification and Overexpression in Hepatocellular Carcinoma Tissues

Table 3

Association between TOP2A overexpression and other variables.

Variables	TOP2A overexpression^†
	Negative; (IHC < 10%)	Positive; (IHC ≥ 10%)
Tissues
Nontumors	40 (100%)	0 (0%)	<0.001
Tumors	11 (27.5%)	29 (72.5%)
Age
<50	4 (22.2%)	14 (77.8%)	0.499
≥50	7 (31.8%)	15 (68.2%)
Tumor size
<5 cm	11 (78.6%)	3 (21.4%)	0.528
≥5 cm	18 (69.2%)	8 (30.8%)
AFP
<500	7 (29.2%)	17 (70.8%)	0.919
≥500	4 (30.8%)	9 (69.2%)
HBsAg
Negative	7 (58.3%)	5 (41.7%)	0.004
Positive	4 (14.3%)	24 (85.7%)
TP53 expression
Negative	7 (33.3%)	14 (66.7%)	0.442
Positive	4 (22.2%)	14 (77.8%)
Ki-67 expression
<10%	5 (55.6%)	4 (44.4%)	0.038
≥10%	6 (20.0%)	24 (80.0%)
CEP17 copy number
<3 copy	2 (25.0%)	6 (75.0%)	1.000
≥3 copy	3 (25.0%)	9 (75.0%)
TOP2A copy number
<3 copy	1 (16.7%)	5 (83.3%)	1.000
≥3 copy	4 (28.6%)	10 (71.4%)

TOP2A overexpression = TOP2A (IHC) ≥10%.
^†Result given as (%).
Chi-square () test.