Research Article

DNaseI Protects against Paraquat-Induced Acute Lung Injury and Pulmonary Fibrosis Mediated by Mitochondrial DNA

Figure 4

The levels of circulating and BALF mtDNA are elevated in a mouse model of PQ-induced lung injury. ((a)-(b)) C57BL/6 mice injected with PQ (25 mg/kg, i.p., d1 and d3) displayed typical acute lung injury and pulmonary fibrosis compatible with the classic bleomycin (BLM) model. (c) The time course of mtDNA detection differed in the plasma (bar) and BALF (red line).
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