In Vitro Gender-Dependent Inhibition of Porcine Cytochrome P450 Activity by Selected Flavonoids and Phenolic Acids

Figure 1

In vitro inhibition of (a) CYP1A, (b) CYP2A, (c) CYP3A, and (d) CYP2E1 by individual flavonols and phenolic acids (16 μM) in hepatic microsomes from male and female pigs. The following compounds were used: 1, rutin; 2, myricetin; 3, quercetin; 4, isorhamnetin; 5, p-coumaric acid; 6, gallic acid; 7, caffeic acid. Data are presented as the mean percentage of remaining activity and standard error of the enzyme activity for two (for CYP1A, CYP2A) or three (for CYP3A, CYP2E1) individual pools with microsomes from 2 male pigs in each pool and two pools with microsomes from 2 female pigs in each pool.

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