Applying NGS Data to Find Evolutionary Network Biomarkers from the Early and Late Stages of Hepatocellular Carcinoma

Figure 4

Overview of significant pathways of network markers of early-stage liver cancer. KEGG pathways accessed using the DAVID tool (Table 7) show significant associations with specific proteins in the early stage of liver cancer; these molecular pathways are labeled with values of ≤0.05. These pathways were shown to play important roles in the carcinogenesis mechanism in the early stage of liver cancer. Network markers of the early stage of liver cancer as highlighted by stars show potential targets in the pathways. Due to different naming systems, the same proteins in the tables and text have different names. The proteins in the early-stage liver cancer network marker are enriched in “hsa03040:Mismatch repair” (Rank 9 in Table 7).