Applying NGS Data to Find Evolutionary Network Biomarkers from the Early and Late Stages of Hepatocellular Carcinoma

Table 2

The 27 identified significant proteins of core network marker in both early-stage and late-stage liver cancer (intersection).

Common network marker of early-stage and late-stage liver cancer
Protein	CRV	value	Cancer_AvgExp	Control_AvgExp
APP	46.52	0.00001	13724	14041	−0.03
APP	13.87	0.00066	15083	14041	0.1
ELAVL1	22.99	0.00033	1725	1319	0.39
ELAVL1	29.69	0.00003	1791	1319	0.44
KRTAP10-5	14.73	0.00098	1	1	0.04
KRTAP10-5	20.54	0.00022	1	1	0.06
H2AFX	14.08	0.00105	608	271	1.17
H2AFX	15.43	0.00053	806	271	1.58
CDK1	13.69	0.00108	335	34	3.32
CDK1	10.31	0.00119	596	34	4.15
ESR1	12.81	0.00119	228	1537	−2.76
ESR1	34.1	0.00000	245	1537	−2.65
EZH2	12.22	0.00127	310	49	2.66
EZH2	19.05	0.00027	394	49	3
CEP250	12.05	0.00130	716	268	1.42
CEP250	16.12	0.00045	627	268	1.23
AURKB	11.41	0.00138	141	14	3.35
AURKB	7.68	0.00289	199	14	3.85
CDC20	10.89	0.00152	359	20	4.17
CDC20	8.94	0.00168	688	20	5.11
E2F1	10.54	0.00158	476	43	3.46
E2F1	8.85	0.00174	673	43	3.95
OTX1	10.29	0.00166	31	2	4.27
OTX1	6.25	0.00811	26	2	4.02
SUMO1	9.86	0.00181	2422	2982	−0.3
SUMO1	8.63	0.00188	2624	2982	−0.18
MCM4	9.76	0.00186	1308	336	1.96
MCM4	6.76	0.00535	1327	336	1.98
HGS	7.96	0.00312	2504	1167	1.1
HGS	13.9	0.00066	2441	1167	1.06
KPNA2	7.86	0.00323	1927	689	1.48
KPNA2	10.43	0.00116	2533	689	1.88
UBC	7.85	0.00323	34388	35490	−0.05
UBC	6.63	0.00591	36931	35490	0.06
SPRY2	7.5	0.00376	409	989	−1.27
SPRY2	7.17	0.00399	328	989	−1.59
TOPBP1	7.33	0.00406	799	346	1.21
TOPBP1	6.45	0.00698	875	346	1.34
SIRT7	7.11	0.00456	442	225	0.98
SIRT7	24	0.00012	456	225	1.02
WHSC1	6.67	0.00590	1217	447	1.44
WHSC1	12.06	0.00086	1369	447	1.61
MCM2	6.45	0.00666	1097	174	2.66
MCM2	8.48	0.00200	1351	174	2.96
AURKA	6.4	0.00685	570	86	2.73
AURKA	9.25	0.00154	516	86	2.58
COPS5	6.39	0.00691	1506	1184	0.35
COPS5	10	0.00128	1708	1184	0.53
PCNA	6.29	0.00749	1652	904	0.87
PCNA	15.95	0.00046	2290	904	1.34
BUB1B	6.27	0.00762	179	12	3.89
BUB1B	7.47	0.00327	320	12	4.73
DNMT1	6.02	0.00920	1376	455	1.6
DNMT1	10.63	0.00110	1383	455	1.6

There are two rows with same proteins name while the upper row represents the early stage liver cancer and the lower raw represents the late stage liver cancer.
AvgExp means average expression.
means fold change.