Association of Polymorphisms of the Receptor for Advanced Glycation End Products Gene and Susceptibility to Sporadic Abdominal Aortic Aneurysm
Table 3
Genotype and allele frequencies of RAGE polymorphisms between AAA patients and controls and corresponding ORs for AAA.
Genotype and allele
AAA patients ( = 381)
Controls ( = 436)
OR (95% CI)
valuea
−374T/A (rs1800624)
TT
282 (74.0)
303 (69.5)
0.31
TA
88 (23.1)
115 (26.4)
AA
11 (2.9)
18 (4.1)
TT + TA versus AA
370 (97.1)
418 (95.9)
1.45 (0.68–3.11)
0.34
TT versus TA + AA
99 (26.0)
133 (30.5)
1.25 (0.92–1.70)
0.15
T allele
652 (85.6)
721 (82.7)
1.00
A allele
110 (14.4)
151 (17.3)
1.24 (0.95–1.62)
0.11
−429T/C (rs1800625)
TT
297 (78.0)
344 (78.9)
0.85
TC
77 (20.2)
86 (19.7)
CC
7 (1.8)
6 (1.4)
TT + TC versus CC
374 (98.2)
430 (98.6)
0.75 (0.25–2.24)
0.60
TT versus TC + CC
84 (22.0)
92 (21.1)
0.95 (0.68–1.32)
0.74
T allele
671 (88.1)
774 (88.4)
1.00
C allele
91 (11.9)
98 (11.6)
0.93 (0.69–1.27)
0.66
G82S (rs2070600)
GG
187 (49.1)
258 (59.2)
GS
155 (40.7)
149 (34.2)
SS
39 (10.2)
29 (6.7)
GG + GS versus SS
342 (89.8)
407 (93.3)
0.63 (0.38–1.03)
0.11
GG versus GS + SS
194 (50.9)
178 (40.8)
0.67 (0.50–0.88)
0.010
G allele
529 (69.4)
665 (76.3)
1.00
S allele
233 (30.6)
207 (23.7)
0.71 (0.57–0.88)
0.008
Data are presented as number (%).
aAdjusted for age, gender, smoking, hypertension, diabetes mellitus, and dyslipidemia.
b values under 0.05 were indicated in bold font.