Research Article

Association of Polymorphisms of the Receptor for Advanced Glycation End Products Gene and Susceptibility to Sporadic Abdominal Aortic Aneurysm

Table 3

Genotype and allele frequencies of RAGE polymorphisms between AAA patients and controls and corresponding ORs for AAA.

Genotype and alleleAAA patients
( = 381)
Controls
( = 436)
OR (95% CI) valuea

−374T/A (rs1800624)
 TT282 (74.0)303 (69.5)0.31
 TA 88 (23.1)115 (26.4)
 AA11 (2.9)18 (4.1)
TT + TA versus AA370 (97.1)418 (95.9)1.45 (0.68–3.11)0.34
TT versus TA + AA99 (26.0)133 (30.5)1.25 (0.92–1.70)0.15
T allele 652 (85.6)721 (82.7)1.00
A allele 110 (14.4)151 (17.3)1.24 (0.95–1.62)0.11

−429T/C (rs1800625)
 TT297 (78.0)344 (78.9)0.85
 TC77 (20.2)86 (19.7)
 CC7 (1.8)6 (1.4)
TT + TC versus CC374 (98.2)430 (98.6)0.75 (0.25–2.24)0.60
TT versus TC + CC84 (22.0)92 (21.1)0.95 (0.68–1.32)0.74
T allele671 (88.1)774 (88.4)1.00
C allele 91 (11.9)98 (11.6)0.93 (0.69–1.27)0.66

G82S (rs2070600)
 GG187 (49.1)258 (59.2)
 GS155 (40.7)149 (34.2)
 SS39 (10.2)29 (6.7)
GG + GS versus SS342 (89.8)407 (93.3)0.63 (0.38–1.03)0.11
GG versus GS + SS194 (50.9)178 (40.8)0.67 (0.50–0.88)0.010
G allele 529 (69.4)665 (76.3)1.00
S allele 233 (30.6)207 (23.7)0.71 (0.57–0.88)0.008

Data are presented as number (%).
aAdjusted for age, gender, smoking, hypertension, diabetes mellitus, and dyslipidemia.
b values under 0.05 were indicated in bold font.