Research Article

Development, Characterization, and In Vitro Biological Performance of Fluconazole-Loaded Microemulsions for the Topical Treatment of Cutaneous Leishmaniasis

Table 2

Droplet size, polydispersion index, and zeta potential of FLU-unloaded MEs (F1, F2, and F3) and FLU-loaded MEs (F1D, F2D, and F3D). Each value represents the mean (± standard deviation) of three replicates.

FormulationsDroplet size (nm)PDIZeta potential (mV)

F1180.500 ± 0.721 0.174 ± 0.013−40.000 ± 1.758
F1D181.200 ± 1.6090.228 ± 0.012−38.600 ± 1.967
F2618.933 ± 28.6120.615 ± 0.123−43.000 ± 0.608
F2D928.833 ± 34.1860.703 ± 0.079−45.167 ± 2.316
F3317.800 ± 9.3640.686 ± 0.132−54.567 ± 2.608
F3D357.633 ± 18.2400.568 ± 0.083−55.867 ± 3.044