Research Article
Antidepressant-Like Effect of the Leaves of Pseudospondias microcarpa in Mice: Evidence for the Involvement of the Serotoninergic System, NMDA Receptor Complex, and Nitric Oxide Pathway
Figure 8
Effects of pretreatment of mice with L-arginine (750 mg kg−1, i.p., a precursor of nitric oxide, panel (a)), L-NAME (30 mg kg−1, i.p., a nonselective nitric oxide synthase inhibitor, panel (b)), methylene blue (10 mg kg−1, i.p., an inhibitor of NO synthase and an inhibitor of sGC, panel (c)), and sildenafil (5 mg kg−1, i.p., a phosphodiesterase 5 inhibitor, panel (d)) on PME- (100 mg kg−1, p.o.) induced reduction in immobility time in the TST. Each column represents the mean ± SEM (). ; versus vehicle-treated animals (one-way ANOVA followed by Newman-Keuls’ test). Significant difference between treatments: ; (two-way ANOVA followed by Bonferroni’s test).
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