Prevention of Polyglycolic Acid-Induced Peritoneal Adhesions Using Alginate in a Rat Model

Figure 5

Microscopic findings of HE staining. A1 and A2 show the common changes in the five groups. The PGA fibers decreased in size. The PGA fibers turned into flakes (arrow), with each PGA fiber covered by macrophages and collagen-like materials. B1 and B2 show the specific changes in the fibrin group. Inflammatory cells, mainly lymphocytes, had accumulated. Huge lymph follicles were found around the PGA fibers (3/8 rats). C1 and C2 show the specific changes in the three alginate groups. There were two forms of residual alginate: island formation (IF) due to the accumulation of many macrophages ingesting alginate and a “pool” of alginate (PA) in a free state. The scale bars are 50 μm (A1), 20 μm (A2), 100 μm (B1), 50 μm (B2), 100 μm (C1), and 50 μm (C2).

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