Stem Cell Therapy for Corneal Epithelium Regeneration following Good Manufacturing and Clinical Procedures

Figure 2

Kaplan-Meier survival (success) curves of the 20 cases undergoing cultivated limbal epithelial transplantation (CLET) according to follow-up time (maximum of 36 months) (a) and separated by the origin of cells, allogeneic CLET (b) and autologous CLET (c). Shaded areas represent the confidence bands. Survival analysis showed a probability of success at 1-2 years and at 3 years after CLET of 0.80 (confidence interval [CI] 95%, 0.643–0.996) and 0.75 (CI 95%, 0.582–0.966), respectively, for all cases (a). Allogeneic CLET had a 1-2-year and a 3-year survival probability of 0.667 (CI 95%, 0.420–1) and 0.556 (CI 95%, 0.31–1), respectively (b). The survival probability for autologous CLET was 0.9091 (CI 95%, 0.0867–0.7541) after 1, 2, or 3 years (c). The difference in survival between autografts and allografts was not significant (log-rank test, value: 0.0949).

(a)

(b)

(c)