Stem Cell Therapy for Corneal Epithelium Regeneration following Good Manufacturing and Clinical Procedures
Table 2
Prognostic classification on the potential for visual recovery in patients suffering from limbal stem cell deficiency and scheduled for cultivated limbal epithelial transplantation (CLET).
Visual prognosis
Ocular media opacity
Surgeries judged to be necessary to recover full potential vision
Grade 1
Corneal opacity restricted to anterior cornea (epithelial and anterior stroma)
One surgical procedure: CLET only
Grade 2
Corneal opacity restricted to anterior cornea (as Grade 1) plus another noncorneal reason for visual loss (e.g., cataract)
Two surgical procedures: CLET+ noncorneal surgery (e.g., cataract removal most likely)
Grade 3
Full thickness corneal opacity
Two surgical procedures: CLET+ corneal transplant
Grade 4
Full thickness corneal opacity plus another noncorneal reason for visual loss (e.g., cataract)
Three surgical procedures: CLET+ corneal transplantation-corneal surgery (e.g., cataract removal)
Grade 0
Any grade of corneal opacity plus noncorneal irreversible visual loss (e.g., irreversible retinal pathology, advanced glaucoma)
No potential for gain: CLET performed to avoid globe removal
