Stem Cell Therapy for Corneal Epithelium Regeneration following Good Manufacturing and Clinical Procedures

Table 3

Grading of ocular surface clinical characteristics.

	Ciliary hyperemia [50]	Central corneal epithelial opacity [50]	Central corneal epithelial irregularity [24]	Corneal epithelial integrity		Corneal superficial neovascularization [50]
				Superficial punctate keratitis	Persistent epithelial defect area [24]	Area	Length
Grade 0	White conjunctiva	None	Normal/absent		None	None	None
Grade 1	Widening of the vessels	Mild	Mild		≤1/4	≤1/4	1 mm
Grade 2	Mild hyperemia	Moderate	Moderate		>1/4 and ≤1/2	>1/4 and ≤1/2	2-3 mm
Grade 3	Moderate hyperemia	Severe with faint pupil	Severe		>1/2 and ≤3/4	>1/2 and ≤3/4	4-5 mm
Grade 4	Intense hyperemia	Severe with no visible pupil	N/A		>3/4	>3/4	≥6 mm
Grade 5	N/A	N/A	N/A	>Grade 4	N/A	N/A	N/A

Modified from [51].