Ca²⁺ Signaling in Cytoskeletal Reorganization, Cell Migration, and Cancer Metastasis

Table 2

Roles of store-operated SOC influx on the motility of nonmalignant cells.

Gene(s)/Protein(s)	Cell type	Highlight	Target(s)	Reference
STIM1	Endothelial progenitor cells (EPCs)	STIM1 affects EPCs proliferation and migration after vascular injury by regulating Ca^2+ levels	N.A.	[117]
ORAI1	HEK293	Selective activation of NFAT by ORAI1	NFAT	[118]
STIM1	Endothelial leader cells	Cells employ an integrated and polarized Ca^2+ signalling system for directed cell migration	PLC pathway	[25]
ORAI1	Keratinocytes	ORAI1-mediated Ca^2+ entry enhances the turnover of focal adhesion through PKCβ, calpain, and focal adhesion kinase	PKC pathway	[119]
ORAI1 and STIM1	Retinal pigment epithelial cells (ARPE-19 cell line)	STIM1, ORAI1, ERK 1/2, and Akt determine EGF-mediated cell growth	MAPK pathway	[120]
STIM1	HEK293	STIM regulates focal adhesion dynamics	Focal adhesion	[121]
ORAI1 and STIM1	Airway smooth muscle cell (ASMC)	STIM1 or ORAI1 controls PDGF-mediated ASMC proliferation and chemotactic migration	N.A.	[122]
ORAI1 and STIM1	ASMC	STIM1 and ORAI1 control PDGF-induced cell migration and Ca^2+ influx	N.A.	[123]
STIM1	Intestinal epithelial cell (IEC)	Polyamines control TRPC1-mediated Ca^2+ signaling and cell migration via differential STIM1 and STIM2 levels	TRPC1	[124]
ORAI1 and STIM1	Vascular smooth muscle cells (VSMC)	STIM1- and ORAI1-mediated SOC influx regulates angiotensin II-induced VSMC proliferation	N.A.	[125]
STIM1	EPCs	STIM1 regulates the proliferation and migration of EPCs	N.A.	[126]
ORAI1 and STIM1	VSMC	STIM1 and ORAI1 regulate PDGF-mediated Ca^2+ entry and migration in VSMC	N.A.	[127]
ORAI1 and STIM1	VSMC	Knockdown of STIM1 and ORAI1, but not STIM2, Orai2, or Orai3, reduces VSMC proliferation and migration	N.A.	[128]