Impairment of Neutrophil Migration to Remote Inflammatory Site during Lung Histoplasmosis

Figure 2

Effect of SR-27417 and CP-105,696 administration on PMN numbers in air pouch of C57Bl/6 mice. (a and c) Noninfected mice and (b and d) Hc-infected mice (i.t., 5 × 10⁵ Hc yeast) were pretreated with SR-27417 (0.1 mg/kg) and/or CP-105,696 (1 mg/kg) orally 2 and 16 h, respectively, before infection. (a and b) LTB₄ (0.1 μg) or (c and d) PAF (1 μg) injection (in 1 mL PBS vehicle) into the air pouch. Vehicle-treated mice received an oral administration of 0.5% CMC or water. PMN numbers in air pouch were determined as described in Materials and Methods. Data are the mean ± SEM of = 6–12 (a and b) or of = 6–8 (c and d). versus vehicle noninfected mice (PBS into air pouch); versus noninfected mice (agonist into air pouch). versus infected mice (agonist into air pouch).

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