Angiotensinase C mRNA and Protein Downregulations Are Involved in Ethanol-Deteriorated Left Ventricular Systolic Dysfunction in Spontaneously Hypertensive Rats

Figure 6

Ethanol consumption and the activation of RAS in the SHRs. (a) Representative Western blot of renin protein expression. (b) There was a nonsignificant change in renin protein expression among the groups, although there was an upward trend in the ethanol-treated SHRs. (c) Representative Western blot of angiotensin II protein expression. (d) Significant upregulated angiotensin II protein expression was observed in the ethanol-treated SHRs. (e) Representative Western blot of AT₁R protein expression. (f) A significant upregulated AT₁R protein expression was observed in the ethanol-treated SHRs. (g) Significant downregulated R mRNA expressions were observed in both of SHR and SHR + Et groups. All values are means ± SDs.

(a)

(b)

(c)

(d)

(e)

(f)

(g)