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BioMed Research International
Volume 2015, Article ID 413169, 10 pages
http://dx.doi.org/10.1155/2015/413169
Review Article

Current Status of Research on Osteoporosis after Solid Organ Transplantation: Pathogenesis and Management

Center of Organ Transplantation, The Second Xiangya Hospital of Central South University, Changsha 410011, China

Received 17 August 2015; Revised 29 October 2015; Accepted 29 October 2015

Academic Editor: Rita Rezzani

Copyright © 2015 Gong-bin Lan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Improved survival following organ transplantation has brought to the forefront some long-term complications, among which osteoporosis and associated fractures are the major ones that adversely affect the quality of life in recipients. The pathogenesis of osteoporosis in transplant recipients is complex and multifactorial which may be related to increased bone resorption, decreased bone formation, or both. Studies have shown that the preexisting underlying metabolic bone disorders and the use of immunosuppressive agents are the major risk factors for osteoporosis and fractures after organ transplantation. And rapid bone loss usually occurs in the first 6–12 months with a significant increase in fracture risk. This paper will provide an updated review on the possible pathogenesis of posttransplant osteoporosis and fractures, the natural history, and the current prevention and treatment strategies concerning different types of organ transplantation.