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BioMed Research International
Volume 2015, Article ID 413189, 12 pages
http://dx.doi.org/10.1155/2015/413189
Research Article

Morphological and Biomechanical Differences in the Elastase and AngII apoE−/− Rodent Models of Abdominal Aortic Aneurysms

1Weldon School of Biomedical Engineering, Purdue University, 206 S. Martin Jischke Drive, West Lafayette, IN 47907, USA
2Department of Biomedical Engineering, John A. White, Jr. Engineering Hall, 790 W. Dickson Street, Suite 120, Fayetteville, AR 72701, USA

Received 11 October 2014; Accepted 18 December 2014

Academic Editor: Oreste Gualillo

Copyright © 2015 Evan H. Phillips et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. A. T. Hirsch, Z. J. Haskal, N. R. Hertzer et al., “ACC/AHA 2005 Practice Guidelines for the management of patients with peripheral arterial disease (lower extremity, renal, mesenteric, and abdominal aortic): a collaborative report from the American Association for Vascular Surgery/Society for Vascular S urgery, Society for Cardiovascular Angiography and Interventions, Society for Vascular Medicine and Biology, Society of Interventional Radiology, and the ACC/AHA Task Force on Practice Guidelines (Writing Committee to Develop Guidelines for the Management of Patients With Peripheral Arterial Disease): endorsed by the American Association of Cardiovascular and Pulmonary Rehabilitation; National Heart, Lung, and Blood Institute; Society for Vascular Nursing; TransAtlantic Inter-Society Consensus; and Vascular Disease Foundation,” Circulation, vol. 113, no. 11, pp. e463–e654, 2006. View at Publisher · View at Google Scholar · View at Scopus
  2. A. S. Go, D. Mozaffarian, V. L. Roger et al., “Heart disease and stroke statistics-2013 update: a Report from the American Heart Association,” Circulation, vol. 127, no. 1, pp. e6–e245, 2013. View at Publisher · View at Google Scholar · View at Scopus
  3. F. A. M. V. I. Hellenthal, W. A. Buurman, W. K. W. H. Wodzig, and G. W. H. Schurink, “Biomarkers of abdominal aortic aneurysm progression. Part 2: inflammation,” Nature Reviews Cardiology, vol. 6, no. 8, pp. 543–552, 2009. View at Publisher · View at Google Scholar · View at Scopus
  4. G. M. Longo, W. Xiong, T. C. Greiner, Y. Zhao, N. Fiotti, and B. T. Baxter, “Matrix metalloproteinases 2 and 9 work in concert to produce aortic aneurysms,” The Journal of Clinical Investigation, vol. 110, no. 5, pp. 625–632, 2002. View at Publisher · View at Google Scholar · View at Scopus
  5. K. Saraff, F. Babamusta, L. A. Cassis, and A. Daugherty, “Aortic dissection precedes formation of aneurysms and atherosclerosis in angiotensin II-infused, apolipoprotein E-deficient mice,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 23, no. 9, pp. 1621–1626, 2003. View at Publisher · View at Google Scholar · View at Scopus
  6. D. Petrinec, S. Liao, D. R. Holmes, J. M. Reilly, W. C. Parks, and R. W. Thompson, “Doxycycline inhibition of aneurysmal degeneration in an elastase-induced rat model of abdominal aortic aneurysm: preservation of aortic elastin associated with suppressed production of 92 kD gelatinase,” Journal of Vascular Surgery, vol. 23, no. 2, pp. 336–346, 1996. View at Publisher · View at Google Scholar · View at Scopus
  7. N. Miyama, M. M. Dua, J. J. Yeung et al., “Hyperglycemia limits experimental aortic aneurysm progression,” Journal of Vascular Surgery, vol. 52, no. 4, pp. 975–983, 2010. View at Publisher · View at Google Scholar · View at Scopus
  8. L. Maegdefessel, J. Azuma, R. Toh et al., “Inhibition of microRNA-29b reduces murine abdominal aortic aneurysm development,” The Journal of Clinical Investigation, vol. 122, no. 2, pp. 497–506, 2012. View at Publisher · View at Google Scholar · View at Scopus
  9. S. Anidjar, J.-L. Salzmann, D. Gentric, P. Lagneau, J.-P. Camilleri, and J.-B. Michel, “Elastase-induced experimental aneurysms in rats,” Circulation, vol. 82, no. 3, pp. 973–981, 1990. View at Publisher · View at Google Scholar · View at Scopus
  10. A. Tanaka, T. Hasegawa, Z. Chen, Y. Okita, and K. Okada, “A novel rat model of abdominal aortic aneurysm using a combination of intraluminal elastase infusion and extraluminal calcium chloride exposure,” Journal of Vascular Surgery, vol. 50, no. 6, pp. 1423–1432, 2009. View at Publisher · View at Google Scholar · View at Scopus
  11. R. Pyo, J. K. Lee, J. M. Shipley et al., “Targeted gene disruption of matrix metalloproteinase-9 (gelatinase B) suppresses development of experimental abdominal aortic aneurysms,” The Journal of Clinical Investigation, vol. 105, no. 11, pp. 1641–1649, 2000. View at Publisher · View at Google Scholar · View at Scopus
  12. A. Daugherty, M. W. Manning, and L. A. Cassis, “Angiotensin II promotes atherosclerotic lesions and aneurysms in apolipoprotein E-deficient mice,” The Journal of Clinical Investigation, vol. 105, no. 11, pp. 1605–1612, 2000. View at Publisher · View at Google Scholar · View at Scopus
  13. A. Daugherty and L. A. Cassis, “Mouse models of abdominal aortic aneurysms,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 24, no. 3, pp. 429–434, 2004. View at Publisher · View at Google Scholar · View at Scopus
  14. D. B. Buxton, “Molecular imaging of aortic aneurysms,” Circulation: Cardiovascular Imaging, vol. 5, no. 3, pp. 392–399, 2012. View at Publisher · View at Google Scholar · View at Scopus
  15. B. Martin-Mcnulty, J. Vincelette, R. Vergona, M. E. Sullivan, and Y.-X. Wang, “Noninvasive measurement of abdominal aortic aneurysms in intact mice by a high-frequency ultrasound imaging system,” Ultrasound in Medicine and Biology, vol. 31, no. 6, pp. 745–749, 2005. View at Publisher · View at Google Scholar · View at Scopus
  16. C. Barisione, R. Charnigo, D. A. Howatt, J. J. Moorleghen, D. L. Rateri, and A. Daugherty, “Rapid dilation of the abdominal aorta during infusion of angiotensin II detected by noninvasive high-frequency ultrasonography,” Journal of Vascular Surgery, vol. 44, no. 2, pp. 372–376, 2006. View at Publisher · View at Google Scholar · View at Scopus
  17. G. H. Turner, A. R. Olzinski, R. E. Bernard et al., “In vivo serial assessment of aortic aneurysm formation in apolipoprotein E-deficient mice via MRI,” Circulation: Cardiovascular Imaging, vol. 1, pp. 220–226, 2008. View at Publisher · View at Google Scholar · View at Scopus
  18. J. Azuma, L. Maegdefessel, T. Kitagawa, R. L. Dalman, M. V. McConnell, and P. S. Tsao, “Assessment of elastase-induced murine abdominal aortic aneurysms: comparison of ultrasound imaging with in situ video microscopy,” Journal of Biomedicine and Biotechnology, vol. 2011, Article ID 252141, 10 pages, 2011. View at Publisher · View at Google Scholar · View at Scopus
  19. J. T. Favreau, B. T. Nguyen, I. Gao et al., “Murine ultrasound imaging for circumferential strain analyses in the angiotensin II abdominal aortic aneurysm model,” Journal of Vascular Surgery, vol. 56, no. 2, pp. 462–469, 2012. View at Publisher · View at Google Scholar · View at Scopus
  20. C. J. Goergen, K. N. Barr, D. T. Huynh et al., “In vivo quantification of murine aortic cyclic strain, motion, and curvature: implications for abdominal aortic aneurysm growth,” Journal of Magnetic Resonance Imaging, vol. 32, no. 4, pp. 847–858, 2010. View at Publisher · View at Google Scholar · View at Scopus
  21. C. J. Goergen, J. Azuma, K. N. Barr et al., “Influences of aortic motion and curvature on vessel expansion in murine experimental aneurysms,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 31, no. 2, pp. 270–279, 2011. View at Publisher · View at Google Scholar · View at Scopus
  22. J. D. Humphrey and S. L. Delange, An Introduction to Biomechanics, Springer, New York, NY, USA, 2004.
  23. T. T. Le, I. M. Langohr, M. J. Locker, M. Sturek, and J.-X. Cheng, “Label-free molecular imaging of atherosclerotic lesions using multimodal nonlinear optical microscopy,” Journal of Biomedical Optics, vol. 12, no. 5, Article ID 054007, 10 pages, 2007. View at Publisher · View at Google Scholar · View at Scopus
  24. J. H. N. Lindeman, B. A. Ashcroft, J.-W. M. Beenakker et al., “Distinct defects in collagen microarchitecture underlie vessel-wall failure in advanced abdominal aneurysms and aneurysms in Marfan syndrome,” Proceedings of the National Academy of Sciences of the United States of America, vol. 107, no. 2, pp. 862–865, 2010. View at Publisher · View at Google Scholar · View at Scopus
  25. F. A. Lederle, G. R. Johnson, S. E. Wilson et al., “Prevalence and associations of abdominal aortic aneurysm detected through screening,” Annals of Internal Medicine, vol. 126, no. 6, pp. 441–449, 1997. View at Publisher · View at Google Scholar · View at Scopus
  26. J. A. van Herwaarden, B. E. Muhs, K. L. Vincken et al., “Aortic compliance following EVAR and the influence of different endografts: determination using dynamic MRA,” Journal of Endovascular Therapy, vol. 13, no. 3, pp. 406–414, 2006. View at Publisher · View at Google Scholar · View at Scopus
  27. L. A. Pape, T. T. Tsai, E. M. Isselbacher et al., “Aortic diameter ≥5.5 cm is not a good predictor of type A aortic dissection: observations from the International Registry of Acute Aortic Dissection (IRAD),” Circulation, vol. 116, no. 10, pp. 1120–1127, 2007. View at Publisher · View at Google Scholar · View at Scopus
  28. B. S. Knipp, G. Ailawadi, V. V. Sullivan et al., “Ultrasound measurement of aortic diameters in rodent models of aneurysm disease,” Journal of Surgical Research, vol. 112, no. 1, pp. 97–101, 2003. View at Publisher · View at Google Scholar · View at Scopus
  29. M. A. Bartoli, F. Kober, P. Cozzone, R. W. Thompson, M. C. Alessi, and M. Bernard, “In vivo assessment of murine elastase-induced abdominal aortic aneurysm with high resolution magnetic resonance imaging,” European Journal of Vascular and Endovascular Surgery, vol. 44, no. 5, pp. 475–481, 2012. View at Publisher · View at Google Scholar · View at Scopus
  30. R. Y. Cao, T. Amand, M. D. Ford, U. Piomelli, and C. D. Funk, “The murine angiotensin II-induced abdominal aortic aneurysm model: rupture risk and inflammatory progression patterns,” Frontiers in Pharmacology, vol. 1, p. 9, 2010. View at Publisher · View at Google Scholar
  31. M. D. Ford, A. T. Black, R. Y. Cao, C. D. Funk, and U. Piomelli, “Hemodynamics of the mouse abdominal aortic aneurysm,” Journal of Biomechanical Engineering, vol. 133, no. 12, Article ID 121008, 2011. View at Publisher · View at Google Scholar · View at Scopus
  32. X. Zhang, S. Thatcher, C. Wu, A. Daugherty, and L. A. Cassis, “Castration of male mice prevents the progression of established angiotensin II-induced abdominal aortic aneurysms,” Journal of Vascular Surgery, 2014. View at Publisher · View at Google Scholar · View at Scopus
  33. Y.-X. Wang, B. Martin-McNulty, A. D. Freay et al., “Angiotensin II increases urokinase-type plasminogen activator expression and induces aneurysm in the abdominal aorta of apolipoprotein E-deficient mice,” The American Journal of Pathology, vol. 159, no. 4, pp. 1455–1464, 2001. View at Publisher · View at Google Scholar · View at Scopus
  34. T. Takayanagi, K. J. Crawford, T. Kobayashi et al., “Caveolin 1 is critical for abdominal aortic aneurysm formation induced by angiotensin II and inhibition of lysyl oxidase,” Clinical Science, vol. 126, no. 11, pp. 785–794, 2014. View at Publisher · View at Google Scholar · View at Scopus
  35. J. Z. Cui, A. Y. Tehrani, K. A. Jett, P. Bernatchez, C. van Breemen, and M. Esfandiarei, “Quantification of aortic and cutaneous elastin and collagen morphology in Marfan syndrome by multiphoton microscopy,” Journal of Structural Biology, vol. 187, no. 3, pp. 242–253, 2014. View at Publisher · View at Google Scholar
  36. D. Haskett, M. Azhar, U. Utzinger, and J. P. Vande Geest, “Progressive alterations in microstructural organization and biomechanical response in the ApoE mouse model of aneurysm,” Biomatter, vol. 3, no. 3, Article ID e24648, 2013. View at Publisher · View at Google Scholar