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BioMed Research International
Volume 2015, Article ID 418681, 14 pages
Research Article

Elevated Serum Levels of Cysteine and Tyrosine: Early Biomarkers in Asymptomatic Adults at Increased Risk of Developing Metabolic Syndrome

1Science and Research Centre, University of Primorska, Garibaldijeva 1, SI-6000 Koper, Slovenia
2Faculty of Health Sciences, University of Primorska, Polje 42, SI-6310 Izola, Slovenia
3Department of Medical, Surgical and Health Sciences, Division of Internal Medicine, AOUTS, University of Trieste, Strada di Fiume 447, 34149 Trieste, Italy
4Clinica Medica, Ospedale di Cattinara, Strada di Fiume 149, 34149 Trieste, Italy

Received 15 October 2014; Accepted 15 January 2015

Academic Editor: Li Chen

Copyright © 2015 Nina Mohorko et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


As there is effective intervention for delaying or preventing metabolic diseases, which are often present for years before becoming clinically apparent, novel biomarkers that would mark metabolic complications before the onset of metabolic disease should be identified. We investigated the role of fasting serum amino acids and their associations with inflammatory markers, adipokines, and metabolic syndrome (MetS) components in subjects prior to the onset of insulin resistance (IR). Anthropometric measurements, food records, adipokines, biochemical markers, and serum levels of amino acids were determined in 96 asymptomatic subjects aged 25–49 years divided into three groups according to the number of MetS components present. Cysteine and tyrosine were significantly higher already in group with one component of MetS present compared to subjects without MetS components. Serum amino acid levels correlated with markers of inflammation and adipokines. Alanine and glycine explained 10% of insulin resistance variability. The role of tyrosine and cysteine, that were higher already with 1 component of MetS present, should be further investigated as they might point to future insulin disturbances.