Serological Diagnosis and Follow-Up of Human Cystic Echinococcosis: A New Hope for the Future?

Table 2

Use of antigen B and derivatives for the diagnosis of CE patients (articles published from 2006).

Antigen	Number of CE patients	Confirmatory test	Technique, antibody	Sensitivity (%)	Negative serology more frequent when	Reference
Purified	21	Surgery	Immunochromatography, IgG	100	Not specified	[42]
			Immunochromatography, IgG4	95
	23	Surgery	ELISA, IgG	100	Not specified	[46]
	5	Imaging techniques and serology		80
	13	Serology		0
	32	Imaging techniques	ELISA, IgG	93.8	CE4 and CE5 cyst stages	[16]
	40	Surgery	ELISA, IgG	87.5	Not specified	[30]
			ELISA, IgG4	80
	108	Surgery	DIGFA, IgG	89.8	Cyst location other than liver; CE1, CE4, and CE5 cyst stages; small cysts	[43]
	113	Imaging techniques	DIGFA, IgG	92.9	Not specified	[44]
	35	Imaging techniques	ELISA, IgG	54	CE1, CE4, and CE5 cyst stages	[63]
	56	Surgery	ELISA, all (Protein G)	96.9^1	Not specified	[37]
				82.1^2
Recombinant B1	31	Surgery	ELISA, all (Protein G)	71	Parasite genotype other than G1	[38]
	124	Surgery	ELISA, IgG	83	Not specified	[19]
	246	Imaging techniques	ELISA, all (Protein G)	77.6	Not specified	[64]
	113	Imaging techniques	DIGFA, IgG	77.9	Not specified	[44]
	56	Surgery	ELISA, all (Protein G)	94.6	Not specified	[37]
	123	Imaging techniques	ELISA, IgG	73.9	CE4 and CE5 cyst stages, no pretreatment	[15]
Recombinant B2	54^3	Surgery	ELISA, IgG	77.8	Single cyst, no pretreatment	[17]
	186^4			79
	124	Surgery	ELISA, IgG	62.9	Not specified	[19]
Recombinant 2B2	54^3	Surgery	ELISA, IgG	92.6	Single cyst, no pretreatment	[17]
	186^4			87.6
Recombinant B3	124	Surgery	ELISA, IgG	29	Not specified	[19]
Recombinant B4	124	Surgery	ELISA, IgG	75.8	Not specified	[19]
	36	Surgery	ELISA, IgG	91.7	Not specified	[39]
Recombinant B5	124	Surgery	ELISA, IgG	41.3	Not specified	[19]
P176 peptide	61	Surgery	ELISA, IgG	78.7	Lung cysts, no complications, single cyst, and small cysts	[48]
	63	Surgery	ELISA, IgG	23.8	Not specified	[50]
Long D8-9 peptide	35	Imaging techniques	ELISA IgG	74.3	Not specified	[41]

Positive serology against HF in ELISA IgG, ¹EgAgB purified from a Chinese sheep isolate, ²EgAgB purified from a Iranian sheep isolate, patients selected by their positivity in ELISA IgG against HF, ³Spanish patients, and ⁴Peruvian patients.