Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2015, Article ID 434803, 13 pages
http://dx.doi.org/10.1155/2015/434803
Review Article

The Impact of Microgravity and Hypergravity on Endothelial Cells

1Department of Biomedical and Clinical Sciences “L. Sacco”, Università di Milano, Via Gian Battista Grassi 74, 20157 Milan, Italy
2ASAcampus Joint Laboratory, ASA Research Division, Department of Experimental and Clinical Biomedical Sciences “M. Serio”, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
3Department of Life Sciences, University of Siena, Via A. Moro 2, 53100 Siena, Italy

Received 4 July 2014; Revised 20 October 2014; Accepted 4 November 2014

Academic Editor: Jack J. W. A. Van Loon

Copyright © 2015 Jeanette A. M. Maier et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [49 citations]

The following is the list of published articles that have cited the current article.

  • Ying Gao, Shuai Li, Dan Xu, Junjun Wang, and Yeqing Sun, “ Changes in apoptotic microRNA and mRNA expression profiling in Caenorhabditis elegans during the Shenzhou-8 mission ,” Journal of Radiation Research, pp. rrv050, 2015. View at Publisher · View at Google Scholar
  • Wanting Lin, Yoichi Ezura, Yayoi Izu, Smriti Aryal A.C, Makiri Kawasaki, Pawaputanon Na Mahasarakham Chantida, Keiji Moriyama, and Masaki Noda, “Profilin Expression Is Regulated by Bone Morphogenetic Protein (BMP) in Osteoblastic Cells,” Journal of Cellular Biochemistry, vol. 117, no. 3, pp. 621–628, 2015. View at Publisher · View at Google Scholar
  • Jessica Pietsch, Albert Sickmann, Daniela Grimm, Johann Bauer, Markus Wehland, and Gerhard Weber, “Annotated Gene and Proteome Data Support Recognition of Interconnections Between the Results of Different Experiments in Space Research,” Microgravity Science and Technology, vol. 28, no. 3, pp. 357–365, 2016. View at Publisher · View at Google Scholar
  • Johann Bauer, Markus Bussen, Petra Wise, Markus Wehland, Sabine Schneider, and Daniela Grimm, “Searching the literature for proteins facilitates the identification of biological processes, if advanced methods of analysis are linked: a case study on microgravity-caused changes in cells,” Expert Review of Proteomics, pp. 1–9, 2016. View at Publisher · View at Google Scholar
  • Shing-Chen Lin, Guo-Hau Gou, Ching-Wu Hsia, Cheng-Wen Ho, Kun-Lun Huang, Yung-Fu Wu, Shih-Yu Lee, and Yi-Hui Chen, “Simulated Microgravity Disrupts Cytoskeleton Organization and Increases Apoptosis of Rat Neural Crest Stem Cells via Upregulating CXCR4 Expression and RhoA-ROCK1-p38 MAPK-p53 Signaling,” Stem Cells and Development, 2016. View at Publisher · View at Google Scholar
  • Sayak Mukhopadhyay, Rohini Saha, Anbarasi Palanisamy, Madhurima Ghosh, Anupriya Biswas, Saheli Roy, Arijit Pal, Kathakali Sarkar, and Sangram Bagh, “A systems biology pipeline identifies new immune and disease related molecular signatures and networks in human cells during microgravity exposure,” Scientific Reports, vol. 6, pp. 25975, 2016. View at Publisher · View at Google Scholar
  • Donald E. Watenpaugh, “Analogs of microgravity: head-down tilt and water immersion,” Journal Of Applied Physiology, vol. 120, no. 8, pp. 904–914, 2016. View at Publisher · View at Google Scholar
  • Shen Zhang, Dahan Zheng, Yonggen Wu, Wei Lin, Zaichong Chen, Luhe Meng, Jun Liu, and Ying Zhou, “Simulated Microgravity Using a Rotary Culture System Compromises the In Vitro Development of Mouse Preantral Follicles,” Plos One, vol. 11, no. 3, 2016. View at Publisher · View at Google Scholar
  • Lu Xia, Kwok-Kuen Cheung, Simon S. Yeung, and Ella W. Yeung, “The involvement of transient receptor potential canonical type 1 in skeletal muscle regrowth after unloading-induced atrophy,” The Journal of Physiology, vol. 594, no. 11, pp. 3111–3126, 2016. View at Publisher · View at Google Scholar
  • Xinjian Mao, Zhe Chen, Qing Luo, Bingyu Zhang, and Guanbin Song, “Simulated microgravity inhibits the migration of mesenchymal stem cells by remodeling actin cytoskeleton and increasing cell stiffness,” Cytotechnology, vol. 68, no. 6, pp. 2235–2243, 2016. View at Publisher · View at Google Scholar
  • Daniel T.O. Carvalho, Miguel J.S. Ferreira, Manuela E. Gomes, Jack J.W.A. Van Loon, Pedro L. Granja, Raquel Costa-Almeida, Guilherme Aresta, and Kim Van Der Heiden, “Effects of hypergravity on the angiogenic potential of endothelial cells,” Journal of the Royal Society Interface, vol. 13, no. 124, 2016. View at Publisher · View at Google Scholar
  • Alexander Choukèr, Oliver Ullrich, Svantje Tauber, and Oliver Ullrich, “Cellular Effects of Altered Gravity on the Innate Immune System and the Endothelial Barrier,” The Immune System in Space: Are we prepared?, pp. 19–45, 2016. View at Publisher · View at Google Scholar
  • Alessandra Cazzaniga, Claudia Moscheni, Jeanette AM Maier, and Sara Castiglioni, “Culture of human cells in experimental units for spaceflight impacts on their behavior,” Experimental Biology and Medicine, pp. 153537021668403, 2016. View at Publisher · View at Google Scholar
  • Fei Shi, Tian-Zhi Zhao, Yong-Chun Wang, Xin-Sheng Cao, Chang-Bin Yang, Yuan Gao, Cheng-Fei Li, Jiang-Dong Zhao, Shu Zhang, and Xi-Qing Sun, “The Impact of Simulated Weightlessness on Endothelium-Dependent Angiogenesis and the Role of Caveolae/Caveolin-1,” Cellular Physiology And Biochemistry, vol. 38, no. 2, pp. 502–513, 2016. View at Publisher · View at Google Scholar
  • Gian C. Demontis, Marco M. Germani, Enrico G. Caiani, Ivana Barravecchia, Claudio Passino, and Debora Angeloni, “Human Pathophysiological Adaptations to the Space Environment,” Frontiers in Physiology, vol. 8, 2017. View at Publisher · View at Google Scholar
  • Selvaraj Vimalraj, Kasiviswanathan Dharanibalan, and Suvro Chatterjee, “Stimulated Microgravity and Induction of Angiogenesis; A New Perspective in Wound Healing,” Biochemical Basis and Therapeutic Implications of Angiogenesis, pp. 495–516, 2017. View at Publisher · View at Google Scholar
  • D. Kashirina, L. Pastushkova, M.A. Custaud, I. Dobrokhotov, A. Brzhozovsky, N. Navasiolava, A. Nosovsky, A. Kononikhin, E. Nikolaev, and I. Larina, “Effect of 21-day head down bed rest on urine proteins related to endothelium: Correlations with changes in carbohydrate metabolism,” Acta Astronautica, vol. 137, pp. 122–127, 2017. View at Publisher · View at Google Scholar
  • Qing Luo, Zhe Chen, Lin Yuan, and Guanbin Song, “Microgravity directs stem cell differentiation,” Histology and Histopathology, vol. 32, no. 2, pp. 99–106, 2017. View at Publisher · View at Google Scholar
  • Yimin Weng, Ying Zhou, Shen Zhang, Zhihui Xu, Wenmin Chen, Yonggen Wu, Dahan Zheng, Jun Liu, and Wei Lin, “In vitro growth of mouse preantral follicles under simulated microgravity,” Journal of Visualized Experiments, vol. 2017, no. 130, 2017. View at Publisher · View at Google Scholar
  • Mariano Bizzarri, Maria Grazia Masiello, Alessandro Giuliani, and Alessandra Cucina, “Gravity Constraints Drive Biological Systems Toward Specific Organization Patterns,” BioEssays, pp. 1700138, 2017. View at Publisher · View at Google Scholar
  • Ludmila B. Buravkova, Eugene G. Rudimov, Elena R. Andreeva, and Anatoly I. Grigoriev, “The ICAM-1 expression level determines the susceptibility of human endothelial cells to simulated microgravity,” Journal of Cellular Biochemistry, 2017. View at Publisher · View at Google Scholar
  • Shouli Wang, Zhao Yin, Bei Zhao, Yanmei Qi, Jie Liu, Saum A. Rahimi, Leonard Y. Lee, and Shaohua Li, “Microgravity simulation activates Cdc42 via Rap1GDS1 to promote vascular branch morphogenesis during vasculogenesis,” Stem Cell Research, 2017. View at Publisher · View at Google Scholar
  • C. Morabito, S. Guarnieri, A. Catizone, C. Schiraldi, G. Ricci, and M. A. Mariggiò, “Transient increases in intracellular calcium and reactive oxygen species levels in TCam-2 cells exposed to microgravity,” Scientific Reports, vol. 7, no. 1, 2017. View at Publisher · View at Google Scholar
  • Jiang-Dong Zhao, Xin-Sheng Cao, Yuan Gao, Chao Xie, Fei Shi, Cheng-Fei Li, Shu Zhang, Xi-Qing Sun, Yong-Chun Wang, Ze-Bing Hu, Hong-Yu Xu, Jing Sun, Xiao-Tao Li, and Chang-Bin Yang, “Simulated microgravity promotes angiogenesis through rhoa-dependent rearrangement of the actin cytoskeleton,” Cellular Physiology and Biochemistry, vol. 41, no. 1, pp. 227–238, 2017. View at Publisher · View at Google Scholar
  • Na-Ping Tang, Tao-Tao Hui, Jing Ma, and Qi-Bing Mei, “Effects of miR-503-5p on apoptosis of human pulmonary microvascular endothelial cells in simulated microgravity,” Journal of Cellular Biochemistry, 2018. View at Publisher · View at Google Scholar
  • Yu Zhang, Chunxiang Hu, and Maobin Chen, “Induced Exopolysaccharide Synthesis and the Molecular Mechanism in Synechocystis sp. PCC 6803 Under Clinorotation,” Microgravity Science and Technology, 2018. View at Publisher · View at Google Scholar
  • Ning Li, Chengzhi Wang, Shujin Sun, Chen Zhang, Dongyuan Lü, Qin Chen, and Mian Long, “Microgravity-Induced Alterations of Inflammation-Related Mechanotransduction in Endothelial Cells on Board SJ-10 Satellite,” Frontiers in Physiology, vol. 9, 2018. View at Publisher · View at Google Scholar
  • Dan Xu, Yu-Bing Guo, Min Zhang, and Ye-Qing Sun, “The subsequent biological effects of simulated microgravity on endothelial cell growth in HUVECs,” Chinese Journal of Traumatology, 2018. View at Publisher · View at Google Scholar
  • Armando Aranda-Anzaldo, and Myrna A.R. Dent, “Landscaping the epigenetic landscape of cancer (Revised Version),” Progress in Biophysics and Molecular Biology, 2018. View at Publisher · View at Google Scholar
  • Raquel Costa-Almeida, Daniel T. O. Carvalho, Miguel J. S. Ferreira, Tamagno Pesqueira, Monica Monici, Jack J.W.A. van Loon, Pedro L. Granja, and Manuela E Gomes, “Continuous exposure to simulated hypergravity induced changes in proliferation, morphology and gene expression of human tendon cells,” Stem Cells and Development, 2018. View at Publisher · View at Google Scholar
  • Daniela Grimm, Marcel Egli, Marcus Krüger, Stefan Riwaldt, Thomas J. Corydon, Sascha Kopp, Markus Wehland, Petra Wise, Manfred Infanger, Vivek Mann, and Alamelu Sundaresan, “Tissue Engineering Under Microgravity Conditions–Use of Stem Cells and Specialized Cells,” Stem Cells and Development, 2018. View at Publisher · View at Google Scholar
  • Aviseka Acharya, Sonja Brungs, Magit Henry, Tamara Rotshteyn, Nirmala Singh Yaduvanshi, Lucia Wegener, Simon Jentzsch, Juergen Hescheler, Ruth Hemmersbach, Helene Boeuf, and Agapios Sachinidis, “Modulation of differentiation processes in murine embryonic stem cells exposed to parabolic flight-induced acute hypergravity and microgravity,” Stem Cells and Development, 2018. View at Publisher · View at Google Scholar
  • Andrey Ratushnyy, Maria Ezdakova, Danila Yakubets, and Ludmila Buravkova, “Angiogenic activity of human adipose-derived mesenchymal stem cells under simulated microgravity,” Stem Cells and Development, 2018. View at Publisher · View at Google Scholar
  • Megumi Hada, Hiroko Ikeda, Jordan Rhone, Andrew Beitman, Ianik Plante, Hikaru Souda, Yukari Yoshida, Kathryn Held, Keigi Fujiwara, Premkumar Saganti, and Akihisa Takahashi, “Increased Chromosome Aberrations in Cells Exposed Simultaneously to Simulated Microgravity and Radiation,” International Journal of Molecular Sciences, vol. 20, no. 1, pp. 43, 2018. View at Publisher · View at Google Scholar
  • Sebastian M. Strauch, Daniela Grimm, Thomas J. Corydon, Marcus Krüger, Johann Bauer, Michael Lebert, Petra Wise, Manfred Infanger, and Peter Richter, “Current knowledge about the impact of microgravity on the proteome,” Expert Review of Proteomics, pp. 1–12, 2018. View at Publisher · View at Google Scholar
  • Ae Jin Jeong, Yoon Jae Kim, Min Hyuk Lim, Haeri Lee, Kumhee Noh, Byung-Hak Kim, Jin Woong Chung, Chung-Hyun Cho, Sungwan Kim, and Sang-Kyu Ye, “Microgravity induces autophagy via mitochondrial dysfunction in human Hodgkin’s lymphoma cells,” Scientific Reports, vol. 8, no. 1, 2018. View at Publisher · View at Google Scholar
  • Nana-Yaw Bimpong-Buta, Christian Jung, Michael Lichtenauer, Maryna Masyuk, Kristina Braun, Peter Jirak, Bernhard Wernly, Johanna Maria Muessig, Sema Kaya, and Malte Kelm, “Analysis of human microcirculation in weightlessness: Study protocol and pre-study experiments,” Clinical Hemorheology and Microcirculation, vol. 70, no. 1, pp. 119–127, 2018. View at Publisher · View at Google Scholar
  • Nan Jiang, Zhengyang Chen, Binbin Li, Song Guo, Ao Li, Tao Zhang, Xiaoyan Fu, Shaoyan Si, and Yan Cui, “Effects of rotary cell culture system‐simulated microgravity on the ultrastructure and biological behavior of human MDA‐MB‐231 breast cancer cells,” Precision Radiation Oncology, 2019. View at Publisher · View at Google Scholar
  • Shujin Sun, Chengzhi Wang, Ning Li, Dongyuan Lü, Qin Chen, and Mian Long, “Cell Growth and Differentiation Under Microgravity,” Life Science in Space: Experiments on Board the SJ-10 Recoverable Satellite, pp. 167–188, 2019. View at Publisher · View at Google Scholar
  • D. Moser, S. J. Sun, N. Li, K. Biere, M. Hoerl, S. Matzel, M. Feuerecker, J.-I. Buchheim, C. Strewe, C. S. Thiel, Y. X. Gao, C. Z. Wang, O. Ullrich, M. Long, and A. Choukèr, “Cells´ Flow and Immune Cell Priming under alternating g-forces in Parabolic Flight,” Scientific Reports, vol. 9, no. 1, 2019. View at Publisher · View at Google Scholar
  • Cheng-Fei Li, Yi-Kai Pan, Yuan Gao, Fei Shi, Yong-Chun Wang, and Xi-Qing Sun, “Autophagy protects HUVECs against ER stress-mediated apoptosis under simulated microgravity,” Apoptosis, 2019. View at Publisher · View at Google Scholar
  • Yong Lan, Yong-Jun Li, Da-Jun Li, Peng Li, Ji-Yang Wang, Yong-Peng Diao, Guo-Dong Ye, and Yang-Fang Li, “Long noncoding RNA MEG3 prevents vascular endothelial cell senescence by impairing miR-128-dependent Girdin downregulation,” American Journal of Physiology-Cell Physiology, vol. 316, no. 6, pp. C830–C843, 2019. View at Publisher · View at Google Scholar
  • Mohamed Zakaria Nassef, Sascha Kopp, Markus Wehland, Daniela Melnik, Jayashree Sahana, Marcus Krüger, Thomas J. Corydon, Hergen Oltmann, Burkhard Schmitz, Andreas Schütte, Thomas J. Bauer, Manfred Infanger, and Daniela Grimm, “Real Microgravity Influences the Cytoskeleton and Focal Adhesions in Human Breast Cancer Cells,” International Journal of Molecular Sciences, vol. 20, no. 13, pp. 3156, 2019. View at Publisher · View at Google Scholar
  • Alessandra Cazzaniga, Laura Locatelli, Sara Castiglioni, and Jeanette A. M. Maier, “The dynamic adaptation of primary human endothelial cells to simulated microgravity,” The FASEB Journal, vol. 33, no. 5, pp. 5957–5966, 2019. View at Publisher · View at Google Scholar
  • Emma M. Woodcock, Paul Girvan, Julia Eckert, Ismael Lopez-Duarte, Markéta Kubánková, Jack J.W.A. van Loon, Nicholas J. Brooks, and Marina K. Kuimova, “Measuring Intracellular Viscosity in Conditions of Hypergravity,” Biophysical Journal, 2019. View at Publisher · View at Google Scholar
  • Daria N. Kashirina, Andrew J. Percy, Liudmila Kh. Pastushkova, Christoph H. Borchers, Kirill S. Kireev, Vladimir A. Ivanisenko, Alexey S. Kononikhin, Eugene N. Nikolaev, and Irina M. Larina, “The molecular mechanisms driving physiological changes after long duration space flights revealed by quantitative analysis of human blood proteins,” BMC Medical Genomics, vol. 12, no. S2, 2019. View at Publisher · View at Google Scholar
  • Lili Wang, Weiyi Chen, Hongmei Guo, and Airong Qian, “Response of membrane tension to gravity in an approximate cell model,” Theoretical Biology and Medical Modelling, vol. 16, no. 1, 2019. View at Publisher · View at Google Scholar
  • Amedeo Amedei, and Lucia Morbidelli, “Circulating Metabolites Originating from Gut Microbiota Control Endothelial Cell Function,” Molecules, vol. 24, no. 21, pp. 3992, 2019. View at Publisher · View at Google Scholar
  • Yi-Kai Pan, Cheng-Fei Li, Yuan Gao, Yong-Chun Wang, and Xi-Qing Sun, “Effect of miR-27b-5p on apoptosis of human vascular endothelial cells induced by simulated microgravity,” Apoptosis, 2019. View at Publisher · View at Google Scholar