Stem Cell-Based Therapies in Chagasic Cardiomyopathy

Figure 1

Venn diagram showing the number of cardiac genes altered in each experimental group. Relative expression was calculated using noninfected mice. Analysis was performed eight months after intraperitoneal injection of 1000 trypomastigotes in both groups and 2 months after treatment in the bone marrow mononuclear cell- (BMMC-) treated group. The seventy genes represented at the intersection of the two spheres were altered in both experimental groups. In the left and right, the total number of genes that had their expression solely affected in the infected and BMMC-treated animals is listed. In total, 1702 genes out of 9390 represented in the array had their expression altered by infection—1222 upregulated and 480 downregulated. When infected animals were treated with the cells, only 180 genes had their expression altered when compared to control—103 upregulated and 77 downregulated.