Developmental Programming of Nonalcoholic Fatty Liver Disease: The Effect of Early Life Nutrition on Susceptibility and Disease Severity in Later Life

Figure 1

An overview of the development of NAFLD in the context of developmental programming. The developmental programming of NAFLD may occur secondarily to programmed obesity and/or via direct programming effects on the liver. Increased lipid accumulation and inflammation in liver can lead to NASH which is the severe form of NAFLD. NASH is associated with hepatic cirrhosis and HCC and carries a significantly increased mortality risk. NAFLD: nonalcoholic fatty liver disease, NASH: nonalcoholic steatohepatitis, HCC: hepatocellular carcinoma.