Multiple Sclerosis in Older Adults: The Clinical Profile and Impact of Interferon Beta Treatment

Figure 3

Multivariable time-dependent Cox regression analysis of potential factors affecting time to reach confirmed and sustained EDSS 6 for 90 interferon beta-exposed patients versus 171 contemporary controls aged ≥50 at baseline, with interferon beta treatment as a time-varying covariate (a). Results of the same analysis for 90 interferon beta-exposed patients and 106 historical controls (b).Ten patients who were censored before the earliest event did not contribute to the analysis. ^†266 person-years of interferon beta exposure and 151 person-years of untreated time (92 person-years before and 59 person-years after the initiation of interferon beta treatment). ^‡597 person-years of untreated time. patients who were censored before the earliest event did not contribute to the analysis. ^||694 person-years of untreated time.

(a) beta-exposed patients^† versus contemporary controls^‡

(b) beta-exposed patients^† versus historical controls^||