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BioMed Research International
Volume 2015, Article ID 451912, 11 pages
Research Article

Multiple Sclerosis in Older Adults: The Clinical Profile and Impact of Interferon Beta Treatment

1Department of Medicine, Division of Neurology and Brain Research Centre, UBC Hospital, University of British Columbia, 2211 Wesbrook Mall, Vancouver, BC, Canada V6T 2B5
2Department of Statistics, University of British Columbia, 3182 Earth Sciences Building, 2207 Main Mall, Vancouver, BC, Canada V6T 1Z4
3College of Pharmacy and Nutrition, University of Saskatchewan, 110 Science Place, Saskatoon, SK, Canada S7N 5C9
4Department of Public Health Sciences, Karolinska Institutet, 171 77 Stockholm, Sweden

Received 5 September 2014; Revised 28 February 2015; Accepted 2 March 2015

Academic Editor: Eberval G. Figueiredo

Copyright © 2015 Afsaneh Shirani et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

In this supplementary material, we present the results of additional analyses including comparison of disability progression from onset to EDSS 6 in patients with either relapsing-onset or primary progressive late-onset MS versus adult-onset MS, as well as several sensitivity analyses to account for patients with an unknown time to EDSS 6 (because EDSS 6 had already been reached at the first clinic visit), and to account for the effect of censoring data once a disease modifying drug was initiated.

  1. Supplementary Material