BioMed Research International / 2015 / Article / Tab 6

Research Article

Identification and Validation of Potential New Biomarkers for Prostate Cancer Diagnosis and Prognosis Using 2D-DIGE and MS

Table 6

Ingenuity pathway analysis of the deregulated proteins in prostate cancer, identified by 2D-DIGE and MS localization; type and top 5 functions of the identified proteins are listed.

IDEntrez gene nameLocalizationTypeFunctions (top 5)

P04217Alpha-1-B glycoproteinExtracellular spaceOther
P08758Annexin A5Plasma membraneOtherCellular assembling and organization, carbohydrate metabolism, and cellular compromise
Q05682Caldesmon 1CytoplasmOtherCellular assembling and organization, cell morphology, and development of connective tissue
P12277Creatine kinase, brainCytoplasmKinase
Q05707Collagen, type XIV, alpha 1Extracellular spaceOtherCellular development and development of connective tissue
P17661DesminCytoplasmOtherCellular assembling and organization, development and function of the cardiovascular system, and organ morphology
P22626Heterogeneous nuclear ribonucleoprotein A2/B1NucleusOtherCellular development
P17987T-complex 1CytoplasmOther
P09493Tropomyosin 1 (alpha)CytoplasmOtherCellular assembling and organization, cell morphology, cellular development, development of connective tissue, development and function of the cardiovascular system, and organ morphology
P08670VimentinCytoplasmOtherCellular assembling and organization, cell morphology, cellular development, development of connective tissue, development and function of the cardiovascular system, and tumor morphology
P04217 Alpha-1-B glycoproteinExtracellular spaceOther
P15309Acid phosphatase, prostateExtracellular spacePhosphatesCellular growth and differentiation, cellular development, and development and function of the hematopoietic system
P09525Annexin A4Plasma membraneOther
P08758Annexin A5Plasma membraneOtherCarbohydrate metabolism, organ development, and development and function of the hematopoietic system
P52907Capping protein (actin filament) muscle Z-line, alpha 1CytoplasmOtherCellular growth and differentiation
P51911Calponin 1, basic, smooth muscleCytoplasmOtherCellular growth and differentiation and cellular development
Q05707Collagen, type XIV, alpha 1Extracellular spaceOtherCellular growth and differentiation, cellular development, and development and function of connective tissues
P12110Collagen, type VI, alpha 2Extracellular spaceOtherCellular growth and differentiation
P16870Carboxypeptidase ECytoplasmPeptidase
Q9UBR2Cathepsin ZCytoplasmPeptidaseCellular growth and differentiation, cellular development, cell morphology, cellular movement (migration), and development and function of the hematopoietic system
P21333Filamin A, alphaCytoplasmOtherCell morphology, cellular movement (migration), and development and function of the cardiovascular system
P11413Glucose-6-phosphate dehydrogenaseCytoplasmEnzymeCellular development, carbohydrate metabolism, organ development, and development and function of the hematopoietic system
P06396GelsolinExtracellular spaceOtherCellular growth and differentiation, cellular movement (invasion), organ development, and development and function of connective tissue
Q16775Hydroxyacylglutathione hydrolaseCytoplasmEnzymeOrgan development
P11021Heat shock 70 kDa protein 5 (glucose-regulated protein, 78 kDa)CytoplasmEnzymeCellular growth and differentiation, cellular development, cellular movement (migration), development and function of the hematopoietic system, and development and function of the cardiovascular system
P01857Immunoglobulin heavy constant gamma 1 (G1m marker)Extracellular spaceOtherCellular growth and differentiation, cellular development, cellular movement (migration, invasion), development and function of the hematopoietic system, and development and function of the cardiovascular system
Q96CX2Potassium channel tetramerization domain containing 12Plasma membraneIon channel
P17931Lectin, galactoside-binding, soluble, 3Extracellular spaceOtherCellular growth and differentiation, cellular development, cell morphology, cellular movement (migration, invasion, and chemotaxis), organ development, development and function of the hematopoietic system, development and function of connective tissue, and development and function of the cardiovascular system
P02545Lamin A/CNucleusOtherCell morphology
P40926Malate dehydrogenase 2, NAD (mitochondrial)CytoplasmEnzyme
P20774OsteoglycinExtracellular spaceGrowth factor
O95394Phosphoglucomutase 3CytoplasmEnzyme
Q13162Peroxiredoxin 4CytoplasmEnzymeCellular growth and differentiation, cellular development, and development and function of connective tissues
Q8N8N7Prostaglandin reductase 2CytoplasmEnzyme
P11216Phosphorylase, glycogen; brainCytoplasmEnzyme
Q12765Secernin 1CytoplasmOther
O15061Synemin, intermediate filament proteinCytoplasmOtherCellular growth and differentiation, cellular development, cell morphology, and cellular movement (migration)
P17987T-complex 1CytoplasmOther
Q5R3I4Tetratricopeptide repeat domain 38unknownOther
P18206VinculinPlasma membraneEnzymeCellular movement (migration) and development and function of connective tissues

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