Activation of Endocannabinoid System Is Associated with Persistent Inflammation in Human Aortic Aneurysm

Figure 1

Activation of the endocannabinoid system in aortic aneurysms. mRNA levels of cannabinoid receptors (a) CB1, (b) CB2, (c) TRPV1, and (d) GPR55 showed a significant increase in aneurysm of ascending aorta (AAA) as compared to the normal aorta of patients with coronary artery disease (CAD). Tissue concentration of the endocannabinoids (c) anandamide (AEA) and (d) 2-arachidonoyl glycerol (2-AG), as well as their degradation products (e) arachidonic acid (AA), and (f) palmitoylethanolamide (PEA) in comparison between the groups. in the AAA group, in the CAD RT-qPCR, and in the CAD LC-MRM group. mRNA levels in RT-qPCR are related to controls and GAPDH using comparative ΔΔCt method. Bracket indicates .

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