Activation of Endocannabinoid System Is Associated with Persistent Inflammation in Human Aortic Aneurysm
Table 1
Preoperative patient data.
CAD
CAD subgroups
AAA
Total
Histology
PCR
LC-MRM
Age (yrs)
69.29 ± 1.19
71.42 ± 1.77
66.67 ± 2.05
70.24 ± 1.86
65.42 ± 2.99
Female gender (%)
21.92
29.17
20.00
24.00
31.58
(16/73)
(7/24)
(6/30)
(5/25)
(6/19)
BMI
27.24 ± 0.72
27.69 ± 3.87
27.96 ± 4.29
27.08 ± 0.81
27.60 ± 0.46
Coronary artery disease (%)
100.00
100.00
100.00
100.00
15.79
(73/73)
(24/24)
(30/30)
(25/25)
(3/19)
Mean aneurysm diameter (cm)
5.40 ± 0.14
AAA (%)
0.00
0.00
0.00
0.00
100.00
(0/73)
(0/24)
(0/30)
(0/25)
(19/19)
Aortic valve regurgitation (%)
9.59
8.34
6.67
12.00
57.90
(7/73)
(2/24)
(2/30)
(3/25)
(11/19)
Aortic valve stenosis (%)
13.70
16.67
16.67
4.00
21.05
(10/73)
(4/24)
(5/30)
(1/25)
(4/19)
Bicuspid aortic valve
1.37
0.00
1.37
0.00
21.05
(1/73)
(0/24)
(1/30)
(0/25)
(4/19)
Ejection fraction (%)
55.32 ± 1.35
58.92 ± 2.48
54.17 ± 2.13
52.96 ± 1.80
55.89 ± 2.43
Atrial fibrillation (%)
19.18
29.17
13.33
12.00
15.79
(14/73)
(7/24)
(4/30)
(3/25)
(3/19)
Hypertension (%)
93.15
83.33
96.67
100
68.42
(68/73)
(20/24)
(29/30)
(25/25)
(13/19)
Stroke (%)
20.55
12.50
23.33
20.00
5.26
(15/73)
(3/24)
(7/30)
(5/20)
(1/19)
Diabetes (%)
41.10
16.67
50.00
44.00
5.26
(30/73)
(4/24)
(15/30)
(11/25)
(1/19)
COPD (%)
5.48
0.00
6.67
8.00
5.26
(4/73)
(0/24)
(2/30)
(2/25)
(1/19)
Renal dysfunction (%)
16.44
8.33
13.33
24.00
5.26
(12/73)
(2/24)
(4/30)
(6/25)
(1/19)
Creatinine (mg/dL)
1.05 ± 0.04
0.97 ± 0.05
1.05 ± 0.05
1.15 ± 0.08
1.02 ± 0.04
Troponin (ng/dL)
0.39 ± 0.17
0.18 ± 0.097
0.65 ± 0.44
0.23 ± 0.12
0.03 ± 0.01
Hemoglobin (g/dL)
13.77 ± 0.18
13.87 ± 0.3
13.63 ± 0.3
13.50 ± 0.35
14.27 ± 0.27
WBC count (G/L)
7.8 ± 0.26
8.09 ± 0.4
7.7 ± 0.41
7.43 ± 0.49
6.45 ± 0.3
CRP (mg/L)
6.60 ± 1.87
4.19 ± 0.87
4.18 ± 1.01
6.04 ± 2.09
4.80 ± 2.12
Renal dysfunction was defined with serum creatinine above the normal range of 0.6–1.3 mg/dL. Normal range of laboratory parameters are troponin <0.05 ng/mL, haemoglobin 12.0–15.4 g/dL, WBC count 3.9–10.2 G/L, and CRP < 3 mg/L. CAD: coronary artery disease, AAA: aneurysm of ascending aorta, BMI: body mass index, COPD: chronic obstructive pulmonary disease, WBC: white blood cell, and CRP: C-reactive protein. Data presented as mean ± SEM. versus AAA.
