BioMed Research International / 2015 / Article / Tab 2

Clinical Study

Improvement of BMI after Lifestyle Intervention Is Associated with Normalisation of Elevated ELF Score and Liver Stiffness in Obese Children

Table 2

Hepatic involvement in obese study group at baseline in comparison to healthy controls or laboratory reference range.

Obese cohort 
median (range)
Healthy controls 
median (range)

ALT (ULN 39 U/L)19 U/L (10–60)

AST (ULN 41 U/L)23 U/L (10–41)

GGT (UNL 44 U/L)22 U/L (3–44)

Bilirubin (ULN 9 mol/L)5 mol/L (2–14)

Transient elastography (ULN 6.5 kPa)5.9 kPa (3.40–8.30) 

Above ULN: (28%)
4.45 kPa (2.45–8.85) 
<0.01
Enhanced liver fibrosis (ELF) test 
cut-off for “any” fibrosis: 9.28
9.0 (7.87–9.60) 

Above 9.28: (21%)
8.6 (7.33–11.52) 
0.033

ALT: alanine aminotransferase; AST: aspartate aminotransferase; GGT: gamma-glutaryl transpeptidase; ULN: upper limit of normal; TE: transient elastography; ELF: enhanced liver fibrosis panel.

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