Improvement of BMI after Lifestyle Intervention Is Associated with Normalisation of Elevated ELF Score and Liver Stiffness in Obese Children

Table 2

Hepatic involvement in obese study group at baseline in comparison to healthy controls or laboratory reference range.

	Obese cohort; median (range)	Healthy controls; median (range)
ALT (ULN 39 U/L)	19 U/L (10–60)
AST (ULN 41 U/L)	23 U/L (10–41)
GGT (UNL 44 U/L)	22 U/L (3–44)
Bilirubin (ULN 9 mol/L)	5 mol/L (2–14)
Transient elastography (ULN 6.5 kPa)	5.9 kPa (3.40–8.30); Above ULN: (28%)	4.45 kPa (2.45–8.85)	<0.01
Enhanced liver fibrosis (ELF) test; cut-off for “any” fibrosis: 9.28	9.0 (7.87–9.60); Above 9.28: (21%)	8.6 (7.33–11.52)	0.033

ALT: alanine aminotransferase; AST: aspartate aminotransferase; GGT: gamma-glutaryl transpeptidase; ULN: upper limit of normal; TE: transient elastography; ELF: enhanced liver fibrosis panel.