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BioMed Research International
Volume 2015 (2015), Article ID 461024, 8 pages
Research Article

Identification of Susceptibility Genes for Peritoneal, Ovarian, and Deep Infiltrating Endometriosis Using a Pooled Sample-Based Genome-Wide Association Study

1Institut Cochin, Université Paris Descartes, Sorbonne Paris Cité, CNRS (UMR 8104), 75014 Paris, France
2Inserm, U1016, 75014 Paris, France
3Université Paris Descartes, Sorbonne Paris Cité, Service de Gynécologie Obstétrique 2 et Médecine de la Reproduction, Hôpital Cochin, Hôpitaux Universitaires Paris Centre, AP-HP, 74014 Paris, France
4Laboratoire Epigénétique et Environnement, Centre National de Génotypage, Institut de Génomique/CEA, 91000 Evry, France

Received 3 September 2014; Revised 17 December 2014; Accepted 15 January 2015

Academic Editor: Mariela Bilotas

Copyright © 2015 Bruno Borghese et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Supplementary Material includes the technical specifications of the primers used for individual genotyping (Supplemental table 1), the baseline characteristics of all participants (Supplemental table 2) and the discovery cohort (Supplemental table 3). Supplemental table 4 provides the top-ranked SNPs significantly associated with at least one endometriosis subtype. Non-supervised gene functional clustering considering genes nearby the 280 top-ranked SNPs is figured in Supplemental table 5. Supplemental tables 6 to 8 provide the results of the replication study: distribution of genotype frequencies in cases and controls for the entire cohort (Supplemental table 6), for the DIE subtypes (Supplemental table 7) and for the OMA subtype (Supplemental table 8).

  1. Supplementary Material