Robust Association Tests for the Replication of Genome-Wide Association Studies

Figure 1

Empirical powers based on 2,000 simulations for markers, genotype relative risks of both stages = 1.4, and disease prevalence under the recessive, additive, and dominant models. 1,000 cases and 1,000 controls are considered to control . The first stage type I error rate for discovery is . Six test statistics, , , MAX3, MIN2, GMS, and GME, are considered. The first, second, and third columns depict powers using the replication-based test, , and , respectively.