Fully Automated Quantification of the Striatal Uptake Ratio of [^99mTc]-TRODAT with SPECT Imaging: Evaluation of the Diagnostic Performance in Parkinson’s Disease and the Temporal Regression of Striatal Tracer Uptake

Table 5

The ROC analysis for the discrimination tasks based on the SRR calculated with the conventional method, which applies predetermined VOIs to the spatially normalized images. Better discrimination power was achieved with the inversely transformed VOIs using our new method, as shown in Table 3.

	Versus nPD group					Versus healthy controls					Versus essential tremor subjects
	Cutoff	Sensitivity	Specificity	Accuracy	AUC	Cutoff	Sensitivity	Specificity	Accuracy	AUC	Cutoff	Sensitivity	Specificity	Accuracy	AUC
PD group	1.65	82.7	90.2	83.8	0.91	1.66	84.1	92.9	84.7	0.93	1.71	92.1	81.8	91.2	0.90
Grou	1.65	84.7	90.2	86.6	0.92	1.66	87.3	92.9	88.4	0.94	1.71	94.9	81.8	92.1	0.90
Grou	1.69	87.0	83.6	85.7	0.91	1.69	87.0	85.7	86.7	0.93	1.71	90.0	81.8	88.0	0.90
Grou	1.65	82.8	90.2	85.8	0.91	1.66	83.9	92.9	86.1	0.92	1.71	90.8	81.8	88.3	0.90
Grou	1.69	88.3	83.6	86.0	0.92	1.66	83.3	92.9	86.4	0.93	1.71	91.7	81.8	88.2	0.91