Chronic Ingestion of High Dosed Phikud Navakot Extraction Induces Mesangiolysis in Rats with Alteration of AQP1 and Hsp60 Expressions

Table 2

Sprague Dawley mean blood clinical chemistry value in chronic oral toxicity test.

Group	GLU; (mg/dL)	BUN; (mg/dL)	CREA; (mg/dL)	CHOL; (mg/dL)	TG; (mg/dL)	URIC; (mg/dL)	TP; (g/dL)	ALB; (g/dL)	GLOB; (g/dL)	Bili-T; (U/L)	AST; (U/L)	ALT; (U/L)	ALP; (U/L)
Male
Control
Mean	137.56	23.21	0.66	230.29	192.29	1.64	9.43	4.80	4.63	0.19	99.29	68.76	80.29
SD	15.30	2.17	0.09	48.24	64.14	0.52	1.24	0.56	0.78	0.02	18.07	16.94	18.56
10 mg/kg
Mean	155.22	23.73	0.66	256.08	210.08	1.82	9.26	4.62	4.64	0.17	95.73	68.29	77.38
SD	35.92	3.12	0.11	60.33	68.66	0.68	0.89	0.37	0.65	0.03	14.04	14.99	16.43
100 mg/kg
Mean	162.46	24.98	0.70	264.50	194.92	2.18	9.89	5.01	4.88	2.17	100.20	69.98	81.50
SD	29.86	4.34	0.14	53.29	51.49	0.53	0.88	0.65	0.52	6.87	21.01	20.43	14.06
1,000 mg/kg
Mean	182.29	24.81	0.60	279.82	211.91	2.73	9.23	4.61	4.62	0.15	80.11	58.26	80.18
SD	38.54	2.87	0.14	84.66	97.57	0.85	1.05	0.45	0.84	0.04	22.03	11.19	9.10
Female
Control
Mean	185.88	23.06	0.70	173.50	115.71	2.38	10.34	5.94	4.41	0.27	141.31	73.76	41.29
SD	41.89	2.89	0.08	31.71	20.01	0.81	0.83	0.44	0.48	0.06	19.97	14.02	7.28
10 mg/kg
Mean	168.03	22.10	0.64	173.79	131.57	2.34	9.74	5.67	4.06	0.23	137.86	69.34	40.36
SD	35.19	2.41	0.10	35.43	26.26	0.79	1.11	0.55	0.66	0.06	29.51	18.77	11.04
100 mg/kg
Mean	157.04	22.67	0.66	180.00	119.09	1.89	10.59	5.98	4.62	0.27	149.45	77.83	47.45
SD	23.06	3.57	0.09	48.49	30.03	0.46	1.09	0.60	0.59	0.09	28.34	15.41	13.38
1,000 mg/kg
Mean	158.46	24.34	0.63	176.00	120.00	1.96	10.04	5.76	4.30	0.21	126.00	57.00	42.78
SD	27.49	4.15	0.13	36.24	36.48	0.68	1.13	0.49	0.77	0.04	39.37	21.07	23.87

GLU: glucose, BUN: blood urea nitrogen, CREA: creatinine, CHOL: cholesterol, TG: triglyceride, TP: total protein, ALB: albumin, GLOB: globulin, Bili-T: total bilirubin, AST: aspartate aminotransferase, ALT: alanine transaminase, and ALP: alkaline phosphatase.