An Upgrade on the Rabbit Model of Anthracycline-Induced Cardiomyopathy: Shorter Protocol, Reduced Mortality, and Higher Incidence of Overt Dilated Cardiomyopathy

Table 2

Haematological parameters.

Parameter	Basal	Intermediate	Final
RBC (10^6/μL)
Control	5.95 ± 0.24	5.93 ± 0.12	6.12 ± 0.20
DOX2	6.06 ± 0.20	4.76 ± 0.26	5.44 ± 0.74
DAU3	6.29 ± 0.27	4.87 ± 0.19	3.83 ± 0.87
DAU4	6.33 ± 0.25	4.84 ± 0.20	5.23 ± 0.23
Haematocrit (%)
Control	36.93 ± 1.76	36.88 ± 0.61	39.53 ± 0.90
DOX2	37.11 ± 1.75	28.42 ± 1.54	33.29 ± 2.67
DAU3	36.47 ± 1.10	29.56 ± 0.65	25.40 ± 3.56
DAU4	39.36 ± 0.98	29.16 ± 1.32	33.94 ± 2.46
Hemoglobin (g/dL)
Control	12.52 ± 0.47	11.75 ± 0.23	12.82 ± 0.30
DOX2	12.21 ± 0.63	9.14 ± 0.32	10.40 ± 1.23
DAU3	12.18 ± 0.24	8.68 ± 0.24	6.83 ± 1.08
DAU4	13.07 ± 0.44	9.19 ± 0.40	9.57 ± 0.59
MCV (μm^3)
Control	62.17 ± 2.12	62.35 ± 1.41	62.75 ± 1.78
DOX2	61.18 ± 1.87	59.95 ± 3.18	62.40 ± 3.27
DAU3	58.08 ± 1.52	60.88 ± 1.33	62.33 ± 5.03
DAU4	62.29 ± 1.75	60.28 ± 1.36	64.73 ± 3.15
RDW
Control	13.37 ± 0.74	13.95 ± 0.72	13.42 ± 1.14
DOX2	13.08 ± 0.38	18.44 ± 1.15	17.32 ± 1.34
DAU3	13.48 ± 0.28	20.26 ± 0.83	20.47 ± 1.44
DAU4	12.27 ± 0.41	15.98 ± 0.76	19.78 ± 0.78
WBC (10^3/μL)
Control	5.08 ± 1.22	4.86 ± 0.69	5.05 ± 0.82
DOX2	5.77 ± 0.99	6.52 ± 1.14	5.53 ± 0.76
DAU3	4.42 ± 0.64	2.88 ± 0.46	7.41 ± 0.62
DAU4	5.43 ± 0.63	4.80 ± 0.72	8.59 ± 1.92
Differential count (%)
Neutrophils
Control	15.55 ± 2.52	17.57 ± 1.91	22.78 ± 5.20
DOX2	18.20 ± 3.66	12.78 ± 2.49	25.70 ± 9.89
DAU3	14.10 ± 2.19	10.18 ± 4.35	11.10 ± 0.95
DAU4	31.16 ± 9.79	6.58 ± 1.60	27.44 ± 3.03
Lymphocytes
Control	68.55 ± 5.25	65.48 ± 2.97	63.50 ± 4.68
DOX2	68.38 ± 4.55	70.63 ± 5.21	55.90 ± 10.34
DAU3	73.27 ± 2.67	76.52 ± 5.47	72.20 ± 1.30
DAU4	55.86 ± 8.73	82.56 ± 2.14	57.15 ± 3.47

Intermediate time point values were from samples obtained on week 6 in DOX2 group, on week 8 in DAU3 group, and on week 4 in DAU4 group. RBC, red blood cells; MCV, mean corpuscular volume; RDW, red cell distribution width; WBC, white blood cells. Data expressed as mean ± SEM. Statistical significance is at p < 0.05; compared to basal value; compared to control; compared to DOX2; compared to DAU4.