Computational Approaches to Understanding the Role of Fibroblast-Myocyte Interactions in Cardiac Arrhythmogenesis

Figure 1

Simulations of homotypic Cx43, Cx45, and heterotypic Cx43/Cx45 GJ using the Vogel model. Parameters of the Vogel model were modified using least-squares curve fitting to experimental data. The models reproduce key features of the dynamic properties of GJ channels. The conductance () of the homotypic Cx43 and Cx45 GJs is maximal at = 0 and decreases symmetrically with increased . Comparison of the versus graphs of Cx43 (a) and Cx45 (b) shows that Cx45 has greater sensitivity. This is in accordance with experimental data. Cx43/Cx45 GJs (c) show asymmetric voltage sensitivity, with enhanced sensitivity at negative .

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